Experimental Tools to Study Molecular Recognition within the Nanoparticle Corona
Advancements in optical nanosensor development have enabled the design of sensors using synthetic molecular recognition elements through a recently developed method called Corona Phase Molecular Recognition (CoPhMoRe). The synthetic sensors resulting from these design principles are highly selective...
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| Format: | Article |
| Language: | en_US |
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MDPI AG
2014
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| Online Access: | http://hdl.handle.net/1721.1/91578 https://orcid.org/0000-0002-5832-8522 https://orcid.org/0000-0003-2592-7956 https://orcid.org/0000-0003-2944-808X https://orcid.org/0000-0002-5166-1410 |
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| author | Kruss, Sebastian Landry, Markita Patricia Nelson, Justin Theodore Bisker Raviv, Gili Hana Iverson, Nicole M. Reuel, Nigel F. Strano, Michael S. |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Kruss, Sebastian Landry, Markita Patricia Nelson, Justin Theodore Bisker Raviv, Gili Hana Iverson, Nicole M. Reuel, Nigel F. Strano, Michael S. |
| author_sort | Kruss, Sebastian |
| collection | MIT |
| description | Advancements in optical nanosensor development have enabled the design of sensors using synthetic molecular recognition elements through a recently developed method called Corona Phase Molecular Recognition (CoPhMoRe). The synthetic sensors resulting from these design principles are highly selective for specific analytes, and demonstrate remarkable stability for use under a variety of conditions. An essential element of nanosensor development hinges on the ability to understand the interface between nanoparticles and the associated corona phase surrounding the nanosensor, an environment outside of the range of traditional characterization tools, such as NMR. This review discusses the need for new strategies and instrumentation to study the nanoparticle corona, operating in both in vitro and in vivo environments. Approaches to instrumentation must have the capacity to concurrently monitor nanosensor operation and the molecular changes in the corona phase. A detailed overview of new tools for the understanding of CoPhMoRe mechanisms is provided for future applications. |
| first_indexed | 2024-09-23T10:11:46Z |
| format | Article |
| id | mit-1721.1/91578 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:11:46Z |
| publishDate | 2014 |
| publisher | MDPI AG |
| record_format | dspace |
| spelling | mit-1721.1/915782022-09-26T16:20:59Z Experimental Tools to Study Molecular Recognition within the Nanoparticle Corona Kruss, Sebastian Landry, Markita Patricia Nelson, Justin Theodore Bisker Raviv, Gili Hana Iverson, Nicole M. Reuel, Nigel F. Strano, Michael S. Massachusetts Institute of Technology. Department of Chemical Engineering Landry, Markita Patricia Kruss, Sebastian Nelson, Justin Theodore Bisker Raviv, Gili Hana Iverson, Nicole M. Reuel, Nigel F. Strano, Michael S. Advancements in optical nanosensor development have enabled the design of sensors using synthetic molecular recognition elements through a recently developed method called Corona Phase Molecular Recognition (CoPhMoRe). The synthetic sensors resulting from these design principles are highly selective for specific analytes, and demonstrate remarkable stability for use under a variety of conditions. An essential element of nanosensor development hinges on the ability to understand the interface between nanoparticles and the associated corona phase surrounding the nanosensor, an environment outside of the range of traditional characterization tools, such as NMR. This review discusses the need for new strategies and instrumentation to study the nanoparticle corona, operating in both in vitro and in vivo environments. Approaches to instrumentation must have the capacity to concurrently monitor nanosensor operation and the molecular changes in the corona phase. A detailed overview of new tools for the understanding of CoPhMoRe mechanisms is provided for future applications. Juvenile Diabetes Research Foundation International McGovern Institute for Brain Research at MIT. Neurotechnology (MINT) Program National Science Foundation (U.S.) (Postdoctoral Research Fellowship Award DBI-1306229) Burroughs Wellcome Fund (Grant Award 1013994) German Science Foundation 2014-11-14T18:16:47Z 2014-11-14T18:16:47Z 2014-09 2014-08 Article http://purl.org/eprint/type/JournalArticle 1424-8220 http://hdl.handle.net/1721.1/91578 Landry, Markita, Sebastian Kruss, Justin Nelson, Gili Bisker, Nicole Iverson, Nigel Reuel, and Michael Strano. “Experimental Tools to Study Molecular Recognition Within the Nanoparticle Corona.” Sensors 14, no. 9 (September 2014): 16196–16211. https://orcid.org/0000-0002-5832-8522 https://orcid.org/0000-0003-2592-7956 https://orcid.org/0000-0003-2944-808X https://orcid.org/0000-0002-5166-1410 en_US http://dx.doi.org/10.3390/s140916196 Sensors Creative Commons Attribution http://creativecommons.org/licenses/by/3.0/ application/pdf MDPI AG MDPI |
| spellingShingle | Kruss, Sebastian Landry, Markita Patricia Nelson, Justin Theodore Bisker Raviv, Gili Hana Iverson, Nicole M. Reuel, Nigel F. Strano, Michael S. Experimental Tools to Study Molecular Recognition within the Nanoparticle Corona |
| title | Experimental Tools to Study Molecular Recognition within the Nanoparticle Corona |
| title_full | Experimental Tools to Study Molecular Recognition within the Nanoparticle Corona |
| title_fullStr | Experimental Tools to Study Molecular Recognition within the Nanoparticle Corona |
| title_full_unstemmed | Experimental Tools to Study Molecular Recognition within the Nanoparticle Corona |
| title_short | Experimental Tools to Study Molecular Recognition within the Nanoparticle Corona |
| title_sort | experimental tools to study molecular recognition within the nanoparticle corona |
| url | http://hdl.handle.net/1721.1/91578 https://orcid.org/0000-0002-5832-8522 https://orcid.org/0000-0003-2592-7956 https://orcid.org/0000-0003-2944-808X https://orcid.org/0000-0002-5166-1410 |
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