Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity

Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity

Immunostimulatory agonists such as anti-CD137 and interleukin (IL)-2 have elicited potent antitumor immune responses in preclinical studies, but their clinical use is limited by inflammatory toxicities that result upon systemic administration. We hypothesized that by rigorously restricting the biodi...

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Bibliografische gegevens
Hoofdauteurs: Kwong, Brandon, Gai, S. Annie, Elkhader, Jamal, Wittrup, Karl Dane, Irvine, Darrell J
Andere auteurs: Massachusetts Institute of Technology. Department of Biological Engineering
Formaat: Artikel
Taal:en_US
Gepubliceerd in: American Association for Cancer Research 2014
Online toegang:http://hdl.handle.net/1721.1/91608
https://orcid.org/0000-0003-2398-5896

Internet

http://hdl.handle.net/1721.1/91608
https://orcid.org/0000-0003-2398-5896

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