Roles for MicroRNAs in Conferring Robustness to Biological Processes
Biological systems use a variety of mechanisms to maintain their functions in the face of environmental and genetic perturbations. Increasing evidence suggests that, among their roles as posttranscriptional repressors of gene expression, microRNAs (miRNAs) help to confer robustness to biological pro...
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2014
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| Online Access: | http://hdl.handle.net/1721.1/91629 https://orcid.org/0000-0003-1465-1691 |
| _version_ | 1826212344822235136 |
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| author | Ebert, Margaret S. Sharp, Phillip A. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Ebert, Margaret S. Sharp, Phillip A. |
| author_sort | Ebert, Margaret S. |
| collection | MIT |
| description | Biological systems use a variety of mechanisms to maintain their functions in the face of environmental and genetic perturbations. Increasing evidence suggests that, among their roles as posttranscriptional repressors of gene expression, microRNAs (miRNAs) help to confer robustness to biological processes by reinforcing transcriptional programs and attenuating aberrant transcripts, and they may in some network contexts help suppress random fluctuations in transcript copy number. These activities have important consequences for normal development and physiology, disease, and evolution. Here, we will discuss examples and principles of miRNAs that contribute to robustness in animal systems. |
| first_indexed | 2024-09-23T15:20:14Z |
| format | Article |
| id | mit-1721.1/91629 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:20:14Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/916292022-10-02T02:16:19Z Roles for MicroRNAs in Conferring Robustness to Biological Processes Ebert, Margaret S. Sharp, Phillip A. Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Sharp, Phillip A. Ebert, Margaret S. Biological systems use a variety of mechanisms to maintain their functions in the face of environmental and genetic perturbations. Increasing evidence suggests that, among their roles as posttranscriptional repressors of gene expression, microRNAs (miRNAs) help to confer robustness to biological processes by reinforcing transcriptional programs and attenuating aberrant transcripts, and they may in some network contexts help suppress random fluctuations in transcript copy number. These activities have important consequences for normal development and physiology, disease, and evolution. Here, we will discuss examples and principles of miRNAs that contribute to robustness in animal systems. United States. Public Health Service (Grant R01-CA133404) National Cancer Institute (U.S.) (Cancer Center Support (Core) Grant P30-CA14051) 2014-11-20T13:31:43Z 2014-11-20T13:31:43Z 2012-04 Article http://purl.org/eprint/type/JournalArticle 00928674 1097-4172 http://hdl.handle.net/1721.1/91629 Ebert, Margaret S., and Phillip A. Sharp. “Roles for MicroRNAs in Conferring Robustness to Biological Processes.” Cell 149, no. 3 (April 2012): 515–524. © 2012 Elsevier Inc. https://orcid.org/0000-0003-1465-1691 en_US http://dx.doi.org/10.1016/j.cell.2012.04.005 Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier |
| spellingShingle | Ebert, Margaret S. Sharp, Phillip A. Roles for MicroRNAs in Conferring Robustness to Biological Processes |
| title | Roles for MicroRNAs in Conferring Robustness to Biological Processes |
| title_full | Roles for MicroRNAs in Conferring Robustness to Biological Processes |
| title_fullStr | Roles for MicroRNAs in Conferring Robustness to Biological Processes |
| title_full_unstemmed | Roles for MicroRNAs in Conferring Robustness to Biological Processes |
| title_short | Roles for MicroRNAs in Conferring Robustness to Biological Processes |
| title_sort | roles for micrornas in conferring robustness to biological processes |
| url | http://hdl.handle.net/1721.1/91629 https://orcid.org/0000-0003-1465-1691 |
| work_keys_str_mv | AT ebertmargarets rolesformicrornasinconferringrobustnesstobiologicalprocesses AT sharpphillipa rolesformicrornasinconferringrobustnesstobiologicalprocesses |