Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion
Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate gyrus, are highly active during the first few weeks after functional integration into the neuronal network, distinguishing them from less active, older adult-born GCs and the major population of dentate GCs genera...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier B.V.
2014
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| Online Access: | http://hdl.handle.net/1721.1/91710 https://orcid.org/0000-0003-2839-8228 |
| _version_ | 1826191579481636864 |
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| author | Nakashiba, Toshiaki Cushman, Jesse D. Pelkey, Kenneth A. Renaudineau, Sophie Buhl, Derek L. McHugh, Thomas J. Barrera, Vanessa Rodriguez Chittajallu, Ramesh Iwamoto, Keisuke S. McBain, Chris J. Fanselow, Michael S. Tonegawa, Susumu |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Nakashiba, Toshiaki Cushman, Jesse D. Pelkey, Kenneth A. Renaudineau, Sophie Buhl, Derek L. McHugh, Thomas J. Barrera, Vanessa Rodriguez Chittajallu, Ramesh Iwamoto, Keisuke S. McBain, Chris J. Fanselow, Michael S. Tonegawa, Susumu |
| author_sort | Nakashiba, Toshiaki |
| collection | MIT |
| description | Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate gyrus, are highly active during the first few weeks after functional integration into the neuronal network, distinguishing them from less active, older adult-born GCs and the major population of dentate GCs generated developmentally. To ascertain whether young and old GCs perform distinct memory functions, we created a transgenic mouse in which output of old GCs was specifically inhibited while leaving a substantial portion of young GCs intact. These mice exhibited enhanced or normal pattern separation between similar contexts, which was reduced following ablation of young GCs. Furthermore, these mutant mice exhibited deficits in rapid pattern completion. Therefore, pattern separation requires adult-born young GCs but not old GCs, and older GCs contribute to the rapid recall by pattern completion. Our data suggest that as adult-born GCs age, their function switches from pattern separation to rapid pattern completion. |
| first_indexed | 2024-09-23T08:58:07Z |
| format | Article |
| id | mit-1721.1/91710 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:58:07Z |
| publishDate | 2014 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | mit-1721.1/917102022-09-26T09:31:59Z Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion Nakashiba, Toshiaki Cushman, Jesse D. Pelkey, Kenneth A. Renaudineau, Sophie Buhl, Derek L. McHugh, Thomas J. Barrera, Vanessa Rodriguez Chittajallu, Ramesh Iwamoto, Keisuke S. McBain, Chris J. Fanselow, Michael S. Tonegawa, Susumu Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory RIKEN-MIT Center for Neural Circuit Genetics Nakashiba, Toshiaki Renaudineau, Sophie Buhl, Derek L. McHugh, Thomas J. Tonegawa, Susumu Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate gyrus, are highly active during the first few weeks after functional integration into the neuronal network, distinguishing them from less active, older adult-born GCs and the major population of dentate GCs generated developmentally. To ascertain whether young and old GCs perform distinct memory functions, we created a transgenic mouse in which output of old GCs was specifically inhibited while leaving a substantial portion of young GCs intact. These mice exhibited enhanced or normal pattern separation between similar contexts, which was reduced following ablation of young GCs. Furthermore, these mutant mice exhibited deficits in rapid pattern completion. Therefore, pattern separation requires adult-born young GCs but not old GCs, and older GCs contribute to the rapid recall by pattern completion. Our data suggest that as adult-born GCs age, their function switches from pattern separation to rapid pattern completion. Howard Hughes Medical Institute Otsuka Maryland Research Institute Jeffry M. and Barbara Picower Foundation Eunice Kennedy Shriver National Institute of Child Health and Human Development (U.S.) (NICHD intramural funding) National Institutes of Health (U.S.) (NIH grant R01-MH62122) National Institutes of Health (U.S.) (NIH grant R01-MH078821) National Institutes of Health (U.S.) (NIH grant P50-MH58880) 2014-11-24T17:40:45Z 2014-11-24T17:40:45Z 2012-03 2011-12 Article http://purl.org/eprint/type/JournalArticle 00928674 http://hdl.handle.net/1721.1/91710 Nakashiba, Toshiaki, Jesse D. Cushman, Kenneth A. Pelkey, Sophie Renaudineau, Derek L. Buhl, Thomas J. McHugh, Vanessa Rodriguez Barrera, et al. “Young Dentate Granule Cells Mediate Pattern Separation, Whereas Old Granule Cells Facilitate Pattern Completion.” Cell 149, no. 1 (March 2012): 188–201.© 2012 Elsevier Inc. https://orcid.org/0000-0003-2839-8228 en_US http://dx.doi.org/10.1016/j.cell.2012.01.046 Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier B.V. Elsevier |
| spellingShingle | Nakashiba, Toshiaki Cushman, Jesse D. Pelkey, Kenneth A. Renaudineau, Sophie Buhl, Derek L. McHugh, Thomas J. Barrera, Vanessa Rodriguez Chittajallu, Ramesh Iwamoto, Keisuke S. McBain, Chris J. Fanselow, Michael S. Tonegawa, Susumu Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion |
| title | Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion |
| title_full | Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion |
| title_fullStr | Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion |
| title_full_unstemmed | Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion |
| title_short | Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion |
| title_sort | young dentate granule cells mediate pattern separation whereas old granule cells facilitate pattern completion |
| url | http://hdl.handle.net/1721.1/91710 https://orcid.org/0000-0003-2839-8228 |
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