Engineering synthetic vaccines using cues from natural immunity
Vaccines aim to protect against or treat diseases through manipulation of the immune response, promoting either immunity or tolerance. In the former case, vaccines generate antibodies and T cells poised to protect against future pathogen encounter or attack diseased cells such as tumours; in the lat...
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2014
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| Online Access: | http://hdl.handle.net/1721.1/91967 https://orcid.org/0000-0001-7604-1333 |
| _version_ | 1826196059006697472 |
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| author | Swartz, Melody A. Irvine, Darrell J Szeto, Gregory |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Swartz, Melody A. Irvine, Darrell J Szeto, Gregory |
| author_sort | Swartz, Melody A. |
| collection | MIT |
| description | Vaccines aim to protect against or treat diseases through manipulation of the immune response, promoting either immunity or tolerance. In the former case, vaccines generate antibodies and T cells poised to protect against future pathogen encounter or attack diseased cells such as tumours; in the latter case, which is far less developed, vaccines block pathogenic autoreactive T cells and autoantibodies that target self tissue. Enormous challenges remain, however, as a consequence of our incomplete understanding of human immunity. A rapidly growing field of research is the design of vaccines based on synthetic materials to target organs, tissues, cells or intracellular compartments; to co-deliver immunomodulatory signals that control the quality of the immune response; or to act directly as immune regulators. There exists great potential for well-defined materials to further our understanding of immunity. Here we describe recent advances in the design of synthetic materials to direct immune responses, highlighting successes and challenges in prophylactic, therapeutic and tolerance-inducing vaccines. |
| first_indexed | 2024-09-23T10:20:12Z |
| format | Article |
| id | mit-1721.1/91967 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:20:12Z |
| publishDate | 2014 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/919672022-09-30T20:26:35Z Engineering synthetic vaccines using cues from natural immunity Swartz, Melody A. Irvine, Darrell J Szeto, Gregory Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Materials Science and Engineering Ragon Institute of MGH, MIT and Harvard Koch Institute for Integrative Cancer Research at MIT Irvine, Darrell J. Szeto, Gregory Lee Vaccines aim to protect against or treat diseases through manipulation of the immune response, promoting either immunity or tolerance. In the former case, vaccines generate antibodies and T cells poised to protect against future pathogen encounter or attack diseased cells such as tumours; in the latter case, which is far less developed, vaccines block pathogenic autoreactive T cells and autoantibodies that target self tissue. Enormous challenges remain, however, as a consequence of our incomplete understanding of human immunity. A rapidly growing field of research is the design of vaccines based on synthetic materials to target organs, tissues, cells or intracellular compartments; to co-deliver immunomodulatory signals that control the quality of the immune response; or to act directly as immune regulators. There exists great potential for well-defined materials to further our understanding of immunity. Here we describe recent advances in the design of synthetic materials to direct immune responses, highlighting successes and challenges in prophylactic, therapeutic and tolerance-inducing vaccines. United States. Dept. of Defense (contract W911NF-13-D-0001) United States. Dept. of Defense (contract W911NF-07-D-0004) National Institutes of Health (U.S.) (AI095109) Bill & Melinda Gates Foundation Ragon Institute of MGH, MIT, and Harvard National Institutes of Health (U.S.) (AI091693) Howard Hughes Medical Institute (Investigator) Carigest SA 2014-12-01T18:53:03Z 2014-12-01T18:53:03Z 2013-10 2013-02 Article http://purl.org/eprint/type/JournalArticle 1476-1122 1476-4660 http://hdl.handle.net/1721.1/91967 Irvine, Darrell J., Melody A. Swartz, and Gregory L. Szeto. “Engineering Synthetic Vaccines Using Cues from Natural Immunity.” Nature Materials 12, no. 11 (October 23, 2013): 978–990. https://orcid.org/0000-0001-7604-1333 en_US http://dx.doi.org/10.1038/nmat3775 Nature Materials Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Nature Publishing Group PMC |
| spellingShingle | Swartz, Melody A. Irvine, Darrell J Szeto, Gregory Engineering synthetic vaccines using cues from natural immunity |
| title | Engineering synthetic vaccines using cues from natural immunity |
| title_full | Engineering synthetic vaccines using cues from natural immunity |
| title_fullStr | Engineering synthetic vaccines using cues from natural immunity |
| title_full_unstemmed | Engineering synthetic vaccines using cues from natural immunity |
| title_short | Engineering synthetic vaccines using cues from natural immunity |
| title_sort | engineering synthetic vaccines using cues from natural immunity |
| url | http://hdl.handle.net/1721.1/91967 https://orcid.org/0000-0001-7604-1333 |
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