Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

A coding polymorphism (Thr300Ala) in the essential autophagy gene, autophagy related 16-like 1 (ATG16L1), confers increased risk for the development of Crohn disease, although the mechanisms by which single disease-associated polymorphisms contribute to pathogenesis have been difficult to dissect gi...

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Бібліографічні деталі
Автори: Lassen, Kara G., Kuballa, Petric, Conway, Kara L., Patel, Khushbu, Becker, Christine E., Peloquin, Joanna M., Villablanca, Eduardo J., Norman, Jason M., Liu, Ta-Chung, Heath, Robert J. W., Becker, Morgan L., Fagbami, Lola, Horn, Heiko, Mercer, Johnathan, Yilmaz, Omer, Jaffe, Jacob D., Shamji, Alykhan F., Bahn, Atul K., Carr, Steven A., Daly, Mark J., Virgin, Herbert W., Schreiber, Stuart L., Stappenbeck, Thaddeus S., Xavier, Ramnik J.
Інші автори: Koch Institute for Integrative Cancer Research at MIT
Формат: Стаття
Мова:en_US
Опубліковано: National Academy of Sciences (U.S.) 2014
Онлайн доступ:http://hdl.handle.net/1721.1/91990
https://orcid.org/0000-0002-7577-4612

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