The Cellular Basis for Animal Regeneration
The ability of animals to regenerate missing parts is a dramatic and poorly understood aspect of biology. The sources of new cells for these regenerative phenomena have been sought for decades. Recent advances involving cell fate tracking in complex tissues have shed new light on the cellular underp...
| Main Authors: | , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2014
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| Online Access: | http://hdl.handle.net/1721.1/92026 https://orcid.org/0000-0002-5569-333X |
| _version_ | 1826200092991815680 |
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| author | Tanaka, Elly M. Reddien, Peter |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Tanaka, Elly M. Reddien, Peter |
| author_sort | Tanaka, Elly M. |
| collection | MIT |
| description | The ability of animals to regenerate missing parts is a dramatic and poorly understood aspect of biology. The sources of new cells for these regenerative phenomena have been sought for decades. Recent advances involving cell fate tracking in complex tissues have shed new light on the cellular underpinnings of regeneration in Hydra, planarians, zebrafish, Xenopus, and Axolotl. Planarians accomplish regeneration with use of adult pluripotent stem cells, whereas several vertebrates utilize a collection of lineage-restricted progenitors from different tissues. Together, an array of cellular strategies—from pluripotent stem cells to tissue-specific stem cells and dedifferentiation—are utilized for regeneration. |
| first_indexed | 2024-09-23T11:31:05Z |
| format | Article |
| id | mit-1721.1/92026 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:31:05Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/920262022-09-27T20:01:07Z The Cellular Basis for Animal Regeneration Tanaka, Elly M. Reddien, Peter Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Reddien, Peter The ability of animals to regenerate missing parts is a dramatic and poorly understood aspect of biology. The sources of new cells for these regenerative phenomena have been sought for decades. Recent advances involving cell fate tracking in complex tissues have shed new light on the cellular underpinnings of regeneration in Hydra, planarians, zebrafish, Xenopus, and Axolotl. Planarians accomplish regeneration with use of adult pluripotent stem cells, whereas several vertebrates utilize a collection of lineage-restricted progenitors from different tissues. Together, an array of cellular strategies—from pluripotent stem cells to tissue-specific stem cells and dedifferentiation—are utilized for regeneration. 2014-12-03T19:00:24Z 2014-12-03T19:00:24Z 2011-07 Article http://purl.org/eprint/type/JournalArticle 15345807 1878-1551 http://hdl.handle.net/1721.1/92026 Tanaka, Elly M., and Peter W. Reddien. “The Cellular Basis for Animal Regeneration.” Developmental Cell 21, no. 1 (July 2011): 172–185. © 2011 Elsevier Inc. https://orcid.org/0000-0002-5569-333X en_US http://dx.doi.org/10.1016/j.devcel.2011.06.016 Developmental Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier |
| spellingShingle | Tanaka, Elly M. Reddien, Peter The Cellular Basis for Animal Regeneration |
| title | The Cellular Basis for Animal Regeneration |
| title_full | The Cellular Basis for Animal Regeneration |
| title_fullStr | The Cellular Basis for Animal Regeneration |
| title_full_unstemmed | The Cellular Basis for Animal Regeneration |
| title_short | The Cellular Basis for Animal Regeneration |
| title_sort | cellular basis for animal regeneration |
| url | http://hdl.handle.net/1721.1/92026 https://orcid.org/0000-0002-5569-333X |
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