Cortical Hypersynchrony Predicts Breakdown of Sensory Processing during Loss of Consciousness
Intrinsic cortical dynamics modulates the processing of sensory information and therefore may be critical for conscious perception [1, 2 and 3]. We tested this hypothesis by electroencephalographic recording of ongoing and stimulus-related brain activity during stepwise drug-induced loss of consciou...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2014
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| Online Access: | http://hdl.handle.net/1721.1/92041 |
| _version_ | 1811071356930883584 |
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| author | Supp, Gernot G. Siegel, Markus Hipp, Joerg F. Engel, Andreas K. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Supp, Gernot G. Siegel, Markus Hipp, Joerg F. Engel, Andreas K. |
| author_sort | Supp, Gernot G. |
| collection | MIT |
| description | Intrinsic cortical dynamics modulates the processing of sensory information and therefore may be critical for conscious perception [1, 2 and 3]. We tested this hypothesis by electroencephalographic recording of ongoing and stimulus-related brain activity during stepwise drug-induced loss of consciousness in healthy human volunteers. We found that progressive loss of consciousness was tightly linked to the emergence of a hypersynchronous cortical state in the alpha frequency range (8–14 Hz). This drug-induced ongoing alpha activity was widely distributed across the frontal cortex. Stimulus-related responses to median nerve stimulation consisted of early and midlatency response components in primary somatosensory cortex (S1) and a late component also involving temporal and parietal regions. During progressive sedation, the early response was maintained, whereas the midlatency and late responses were reduced and eventually vanished. The antagonistic relation between the late sensory response and ongoing alpha activity held for constant drug levels on the single-trial level. Specifically, the late response component was negatively correlated with the power and long-range coherence of ongoing frontal alpha activity. Our results suggest blocking of intracortical communication by hypersynchronous ongoing activity as a key mechanism for the loss of consciousness. |
| first_indexed | 2024-09-23T08:49:56Z |
| format | Article |
| id | mit-1721.1/92041 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T08:49:56Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/920412022-09-23T14:50:43Z Cortical Hypersynchrony Predicts Breakdown of Sensory Processing during Loss of Consciousness Supp, Gernot G. Siegel, Markus Hipp, Joerg F. Engel, Andreas K. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Siegel, Markus Intrinsic cortical dynamics modulates the processing of sensory information and therefore may be critical for conscious perception [1, 2 and 3]. We tested this hypothesis by electroencephalographic recording of ongoing and stimulus-related brain activity during stepwise drug-induced loss of consciousness in healthy human volunteers. We found that progressive loss of consciousness was tightly linked to the emergence of a hypersynchronous cortical state in the alpha frequency range (8–14 Hz). This drug-induced ongoing alpha activity was widely distributed across the frontal cortex. Stimulus-related responses to median nerve stimulation consisted of early and midlatency response components in primary somatosensory cortex (S1) and a late component also involving temporal and parietal regions. During progressive sedation, the early response was maintained, whereas the midlatency and late responses were reduced and eventually vanished. The antagonistic relation between the late sensory response and ongoing alpha activity held for constant drug levels on the single-trial level. Specifically, the late response component was negatively correlated with the power and long-range coherence of ongoing frontal alpha activity. Our results suggest blocking of intracortical communication by hypersynchronous ongoing activity as a key mechanism for the loss of consciousness. European Union (Grant IST-2005-027628) European Union (Grant NEST-PATH-043457) European Union (Grant HEALTH-F2-2008-200728) Germany. Federal Ministry of Education and Research (BMBF) State Excellence Initiative (LEXI) Hamburg (Neurodapt) 2014-12-08T14:39:06Z 2014-12-08T14:39:06Z 2011-11 2011-09 Article http://purl.org/eprint/type/JournalArticle 09609822 1879-0445 http://hdl.handle.net/1721.1/92041 Supp, Gernot G., Markus Siegel, Joerg F. Hipp, and Andreas K. Engel. “Cortical Hypersynchrony Predicts Breakdown of Sensory Processing During Loss of Consciousness.” Current Biology 21, no. 23 (December 2011): 1988–1993. © 2011 Elsevier Ltd en_US http://dx.doi.org/10.1016/j.cub.2011.10.017 Current Biology Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier |
| spellingShingle | Supp, Gernot G. Siegel, Markus Hipp, Joerg F. Engel, Andreas K. Cortical Hypersynchrony Predicts Breakdown of Sensory Processing during Loss of Consciousness |
| title | Cortical Hypersynchrony Predicts Breakdown of Sensory Processing during Loss of Consciousness |
| title_full | Cortical Hypersynchrony Predicts Breakdown of Sensory Processing during Loss of Consciousness |
| title_fullStr | Cortical Hypersynchrony Predicts Breakdown of Sensory Processing during Loss of Consciousness |
| title_full_unstemmed | Cortical Hypersynchrony Predicts Breakdown of Sensory Processing during Loss of Consciousness |
| title_short | Cortical Hypersynchrony Predicts Breakdown of Sensory Processing during Loss of Consciousness |
| title_sort | cortical hypersynchrony predicts breakdown of sensory processing during loss of consciousness |
| url | http://hdl.handle.net/1721.1/92041 |
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