Design and implementation of a fiber optic doppler optical coherence microscopy system for cochlear imaging
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2014
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| Online Access: | http://hdl.handle.net/1721.1/92090 |
| _version_ | 1826213619323371520 |
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| author | Williams, Logan P |
| author2 | Dennis M. Freeman. |
| author_facet | Dennis M. Freeman. Williams, Logan P |
| author_sort | Williams, Logan P |
| collection | MIT |
| description | Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014. |
| first_indexed | 2024-09-23T15:52:08Z |
| format | Thesis |
| id | mit-1721.1/92090 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T15:52:08Z |
| publishDate | 2014 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/920902019-04-11T00:34:28Z Design and implementation of a fiber optic doppler optical coherence microscopy system for cochlear imaging Williams, Logan P Dennis M. Freeman. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Electrical Engineering and Computer Science. Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2014. Cataloged from PDF version of thesis. Includes bibliographical references (pages 63-65). In this thesis, the design and implementation of a fiber optic Doppler optical coherence microscopy (FO-DOCM) system for cochlear imaging applications is presented. The use of a fiber optic design significantly reduces system size and complexity and the construction of a novel alignment and micropositioning apparatus increases ease of use for the researcher performing the imaging. To enable precise measurements of tissue motion, a time domain DOCM approach is used, utilizing an acousto-optic modulator (AOM) based optical heterodyne system to generate a stationary interference carrier frequency. By referencing this interference signal against the AOM drive signals, measurements of motions with magnitude on the order of 10 pm are shown to be possible. In addition to interferometrically measuring small amplitude motion, the FO-DOCM system is shown to be capable of imaging with a volumetric resolution of 10 x 9 x 9 pm. Demonstrative results of imaging cochlear tissue are presented by using the FO-DOCM system to image and measure motion in a guinea pig cochlea in vitro. by Logan P. Williams. M. Eng. 2014-12-08T18:48:10Z 2014-12-08T18:48:10Z 2014 2014 Thesis http://hdl.handle.net/1721.1/92090 895676707 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 65 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Electrical Engineering and Computer Science. Williams, Logan P Design and implementation of a fiber optic doppler optical coherence microscopy system for cochlear imaging |
| title | Design and implementation of a fiber optic doppler optical coherence microscopy system for cochlear imaging |
| title_full | Design and implementation of a fiber optic doppler optical coherence microscopy system for cochlear imaging |
| title_fullStr | Design and implementation of a fiber optic doppler optical coherence microscopy system for cochlear imaging |
| title_full_unstemmed | Design and implementation of a fiber optic doppler optical coherence microscopy system for cochlear imaging |
| title_short | Design and implementation of a fiber optic doppler optical coherence microscopy system for cochlear imaging |
| title_sort | design and implementation of a fiber optic doppler optical coherence microscopy system for cochlear imaging |
| topic | Electrical Engineering and Computer Science. |
| url | http://hdl.handle.net/1721.1/92090 |
| work_keys_str_mv | AT williamsloganp designandimplementationofafiberopticdoppleropticalcoherencemicroscopysystemforcochlearimaging |