Implications for Damage Recognition during Dpo4-Mediated Mutagenic Bypass of m1G and m3C Lesions
DNA is susceptible to alkylation damage by a number of environmental agents that modify the Watson-Crick edge of the bases. Such lesions, if not repaired, may be bypassed by Y-family DNA polymerases. The bypass polymerase Dpo4 is strongly inhibited by 1-methylguanine (m1G) and 3-methylcytosine (m3C)...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2014
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| Online Access: | http://hdl.handle.net/1721.1/92256 https://orcid.org/0000-0001-6159-0778 https://orcid.org/0000-0002-2196-5691 |