Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

Transforming growth factor beta (TGF-β) signaling, mediated through the transcription factors Smad2 and Smad3 (Smad2/3), directs different responses in different cell types. Here we report that Smad3 co-occupies the genome with cell-type-specific master transcription factors. Thus, Smad3 occupies th...

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Bibliographic Details
Main Authors: Mullen, Alan C., Orlando, David A., Newman, Jamie Jennifer, Loven, Jakob, Kumar, Roshan M., Bilodeau, Steve, Reddy, Jessica, Guenther, Matthew G., DeKoter, Rodney P., Young, Richard A.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier B.V. 2014
Online Access:http://hdl.handle.net/1721.1/92296
https://orcid.org/0000-0002-2171-9394

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