Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons

Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons

While the abuse of opiate drugs continues to rise, the neuroadaptations that occur with long-term drug exposure remain poorly understood. We describe here a series of chronic morphine-induced adaptations in ventral tegmental area (VTA) dopamine neurons, which are mediated via downregulation of AKT-m...

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Bibliographic Details
Main Authors:	Mazei-Robison, Michelle S., Koo, Ja Wook, Friedman, Allyson K., Lansink, Carien S., Robison, Alfred J., Vinish, Monika, Krishnan, Vaishnav, Kim, Seyun, Siuta, Michael A., Galli, Aurelio, Niswender, Kevin D., Appasani, Raghu, Horvath, Monika C., Neve, Rachael L., Worley, Paul F., Snyder, Solomon H., Hurd, Yasmin L., Cheer, Joseph F., Han, Ming-Hu, Russo, Scott J., Nestler, Eric J.
Other Authors:	Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format:	Article
Language:	en_US
Published:	Elsevier 2014
Online Access:	http://hdl.handle.net/1721.1/92325 https://orcid.org/0000-0002-3854-5968

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