Acetate metabolism in cancer cells
Macromolecule biosynthesis is required to duplicate cell components and support proliferation. Studies examining the nutrients used by cancer cells have focused on the contribution of glucose and glutamine carbon for biosynthesis, but the importance of other metabolic fuels is becoming apparent. Lab...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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BioMed Central Ltd
2014
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| Online Access: | http://hdl.handle.net/1721.1/92358 https://orcid.org/0000-0002-6702-4192 |
| _version_ | 1811097787465465856 |
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| author | Hosios, Aaron M Vander Heiden, Matthew G. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Hosios, Aaron M Vander Heiden, Matthew G. |
| author_sort | Hosios, Aaron M |
| collection | MIT |
| description | Macromolecule biosynthesis is required to duplicate cell components and support proliferation. Studies examining the nutrients used by cancer cells have focused on the contribution of glucose and glutamine carbon for biosynthesis, but the importance of other metabolic fuels is becoming apparent. Labeling of two-carbon units in newly synthesized lipids has been used to infer the nutrients that contribute to the acetyl-CoA pools in cells. Glucose- and glutamine-derived carbon are known to contribute extensively to de novo lipid biosynthesis, and in this issue Kamphorst et al. find that extracellular acetate can also contribute substantially to this process [1]. |
| first_indexed | 2024-09-23T17:04:56Z |
| format | Article |
| id | mit-1721.1/92358 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T17:04:56Z |
| publishDate | 2014 |
| publisher | BioMed Central Ltd |
| record_format | dspace |
| spelling | mit-1721.1/923582022-10-03T10:15:24Z Acetate metabolism in cancer cells Hosios, Aaron M Vander Heiden, Matthew G. Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Vander Heiden, Matthew G. Macromolecule biosynthesis is required to duplicate cell components and support proliferation. Studies examining the nutrients used by cancer cells have focused on the contribution of glucose and glutamine carbon for biosynthesis, but the importance of other metabolic fuels is becoming apparent. Labeling of two-carbon units in newly synthesized lipids has been used to infer the nutrients that contribute to the acetyl-CoA pools in cells. Glucose- and glutamine-derived carbon are known to contribute extensively to de novo lipid biosynthesis, and in this issue Kamphorst et al. find that extracellular acetate can also contribute substantially to this process [1]. 2014-12-17T20:54:56Z 2014-12-17T20:54:56Z 2014 2014-11 2014-12-11T20:50:31Z Article http://purl.org/eprint/type/JournalArticle 2049-3002 http://hdl.handle.net/1721.1/92358 Hosios, Aaron M. and Matthew G. Vander Heiden. "Acetate metabolism in cancer cells." Cancer & Metabolism 2014, 2:27. https://orcid.org/0000-0002-6702-4192 en http://dx.doi.org/10.1186/s40170-014-0027-y Cancer & Metabolism Creative Commons Attribution http://creativecommons.org/licenses/by/4.0 Aaron M Hosios et al.; licensee BioMed Central Ltd. application/pdf BioMed Central Ltd BioMed Central Ltd |
| spellingShingle | Hosios, Aaron M Vander Heiden, Matthew G. Acetate metabolism in cancer cells |
| title | Acetate metabolism in cancer cells |
| title_full | Acetate metabolism in cancer cells |
| title_fullStr | Acetate metabolism in cancer cells |
| title_full_unstemmed | Acetate metabolism in cancer cells |
| title_short | Acetate metabolism in cancer cells |
| title_sort | acetate metabolism in cancer cells |
| url | http://hdl.handle.net/1721.1/92358 https://orcid.org/0000-0002-6702-4192 |
| work_keys_str_mv | AT hosiosaaronm acetatemetabolismincancercells AT vanderheidenmatthewg acetatemetabolismincancercells |