Impact of flow pulsatility on arterial drug distribution in stent-based therapy
Drug-eluting stents reside in a dynamic fluid environment where the extent to which drugs are distributed within the arterial wall is critically modulated by the blood flowing through the arterial lumen. Yet several factors associated with the pulsatile nature of blood flow and their impact on arter...
| Main Authors: | , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier B.V.
2014
|
| Online Access: | http://hdl.handle.net/1721.1/92381 https://orcid.org/0000-0002-7832-7156 https://orcid.org/0000-0002-2890-2319 |
| _version_ | 1826198376533721088 |
|---|---|
| author | O’Brien, Caroline C. Kolachalama, Vijaya Bhasker Barber, Tracie J. Simmons, Anne Edelman, Elazer R. |
| author2 | Institute for Medical Engineering and Science |
| author_facet | Institute for Medical Engineering and Science O’Brien, Caroline C. Kolachalama, Vijaya Bhasker Barber, Tracie J. Simmons, Anne Edelman, Elazer R. |
| author_sort | O’Brien, Caroline C. |
| collection | MIT |
| description | Drug-eluting stents reside in a dynamic fluid environment where the extent to which drugs are distributed within the arterial wall is critically modulated by the blood flowing through the arterial lumen. Yet several factors associated with the pulsatile nature of blood flow and their impact on arterial drug deposition have not been fully investigated. We employed an integrated framework comprising bench-top and computational models to explore the factors governing the time-varying fluid dynamic environment within the vasculature and their effects on arterial drug distribution patterns. A custom-designed bench-top framework comprising a model of a single drug-eluting stent strut and a poly-vinyl alcohol-based hydrogel as a model tissue bed simulated fluid flow and drug transport under fully apposed strut settings. Bench-top experiments revealed a relative independence between drug distribution and the factors governing pulsatile flow and these findings were validated with the in silico model. Interestingly, computational models simulating suboptimal deployment settings revealed a complex interplay between arterial drug distribution, Womersley number and the extent of malapposition. In particular, for a stent strut offset from the wall, total drug deposition was sensitive to changes in the pulsatile flow environment, with this dependence increasing with greater wall displacement. Our results indicate that factors governing pulsatile luminal flow on arterial drug deposition should be carefully considered in conjunction with device deployment settings for better utilization of drug-eluting stent therapy. |
| first_indexed | 2024-09-23T11:03:54Z |
| format | Article |
| id | mit-1721.1/92381 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:03:54Z |
| publishDate | 2014 |
| publisher | Elsevier B.V. |
| record_format | dspace |
| spelling | mit-1721.1/923812022-09-27T16:53:48Z Impact of flow pulsatility on arterial drug distribution in stent-based therapy O’Brien, Caroline C. Kolachalama, Vijaya Bhasker Barber, Tracie J. Simmons, Anne Edelman, Elazer R. Institute for Medical Engineering and Science Harvard University--MIT Division of Health Sciences and Technology O’Brien, Caroline C. Kolachalama, Vijaya Bhasker Edelman, Elazer R. Drug-eluting stents reside in a dynamic fluid environment where the extent to which drugs are distributed within the arterial wall is critically modulated by the blood flowing through the arterial lumen. Yet several factors associated with the pulsatile nature of blood flow and their impact on arterial drug deposition have not been fully investigated. We employed an integrated framework comprising bench-top and computational models to explore the factors governing the time-varying fluid dynamic environment within the vasculature and their effects on arterial drug distribution patterns. A custom-designed bench-top framework comprising a model of a single drug-eluting stent strut and a poly-vinyl alcohol-based hydrogel as a model tissue bed simulated fluid flow and drug transport under fully apposed strut settings. Bench-top experiments revealed a relative independence between drug distribution and the factors governing pulsatile flow and these findings were validated with the in silico model. Interestingly, computational models simulating suboptimal deployment settings revealed a complex interplay between arterial drug distribution, Womersley number and the extent of malapposition. In particular, for a stent strut offset from the wall, total drug deposition was sensitive to changes in the pulsatile flow environment, with this dependence increasing with greater wall displacement. Our results indicate that factors governing pulsatile luminal flow on arterial drug deposition should be carefully considered in conjunction with device deployment settings for better utilization of drug-eluting stent therapy. National Institutes of Health (U.S.) (grant NIH R01 GM-49039) 2014-12-18T17:54:04Z 2014-12-18T17:54:04Z 2013-06 Article http://purl.org/eprint/type/JournalArticle 01683659 http://hdl.handle.net/1721.1/92381 O’Brien, Caroline C., Vijaya B. Kolachalama, Tracie J. Barber, Anne Simmons, and Elazer R. Edelman. “Impact of Flow Pulsatility on Arterial Drug Distribution in Stent-Based Therapy.” Journal of Controlled Release 168, no. 2 (June 2013): 115–124. https://orcid.org/0000-0002-7832-7156 https://orcid.org/0000-0002-2890-2319 en_US http://dx.doi.org/10.1016/j.jconrel.2013.03.014 Journal of Controlled Release Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier B.V. PMC |
| spellingShingle | O’Brien, Caroline C. Kolachalama, Vijaya Bhasker Barber, Tracie J. Simmons, Anne Edelman, Elazer R. Impact of flow pulsatility on arterial drug distribution in stent-based therapy |
| title | Impact of flow pulsatility on arterial drug distribution in stent-based therapy |
| title_full | Impact of flow pulsatility on arterial drug distribution in stent-based therapy |
| title_fullStr | Impact of flow pulsatility on arterial drug distribution in stent-based therapy |
| title_full_unstemmed | Impact of flow pulsatility on arterial drug distribution in stent-based therapy |
| title_short | Impact of flow pulsatility on arterial drug distribution in stent-based therapy |
| title_sort | impact of flow pulsatility on arterial drug distribution in stent based therapy |
| url | http://hdl.handle.net/1721.1/92381 https://orcid.org/0000-0002-7832-7156 https://orcid.org/0000-0002-2890-2319 |
| work_keys_str_mv | AT obriencarolinec impactofflowpulsatilityonarterialdrugdistributioninstentbasedtherapy AT kolachalamavijayabhasker impactofflowpulsatilityonarterialdrugdistributioninstentbasedtherapy AT barbertraciej impactofflowpulsatilityonarterialdrugdistributioninstentbasedtherapy AT simmonsanne impactofflowpulsatilityonarterialdrugdistributioninstentbasedtherapy AT edelmanelazerr impactofflowpulsatilityonarterialdrugdistributioninstentbasedtherapy |