Genetic Evidence for Recent Population Mixture in India
Most Indian groups descend from a mixture of two genetically divergent populations: Ancestral North Indians (ANI) related to Central Asians, Middle Easterners, Caucasians, and Europeans; and Ancestral South Indians (ASI) not closely related to groups outside the subcontinent. The date of mixture is...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2014
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| Online Access: | http://hdl.handle.net/1721.1/92415 https://orcid.org/0000-0002-2724-7228 |
| _version_ | 1826196321758871552 |
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| author | Moorjani, Priya Thangaraj, Kumarasamy Patterson, Nick Lipson, Mark Loh, Po-Ru Govindaraj, Periyasamy Berger, Bonnie Reich, David Singh, Lalji |
| author2 | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
| author_facet | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Moorjani, Priya Thangaraj, Kumarasamy Patterson, Nick Lipson, Mark Loh, Po-Ru Govindaraj, Periyasamy Berger, Bonnie Reich, David Singh, Lalji |
| author_sort | Moorjani, Priya |
| collection | MIT |
| description | Most Indian groups descend from a mixture of two genetically divergent populations: Ancestral North Indians (ANI) related to Central Asians, Middle Easterners, Caucasians, and Europeans; and Ancestral South Indians (ASI) not closely related to groups outside the subcontinent. The date of mixture is unknown but has implications for understanding Indian history. We report genome-wide data from 73 groups from the Indian subcontinent and analyze linkage disequilibrium to estimate ANI-ASI mixture dates ranging from about 1,900 to 4,200 years ago. In a subset of groups, 100% of the mixture is consistent with having occurred during this period. These results show that India experienced a demographic transformation several thousand years ago, from a region in which major population mixture was common to one in which mixture even between closely related groups became rare because of a shift to endogamy. |
| first_indexed | 2024-09-23T10:24:44Z |
| format | Article |
| id | mit-1721.1/92415 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:24:44Z |
| publishDate | 2014 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/924152022-09-26T17:41:54Z Genetic Evidence for Recent Population Mixture in India Moorjani, Priya Thangaraj, Kumarasamy Patterson, Nick Lipson, Mark Loh, Po-Ru Govindaraj, Periyasamy Berger, Bonnie Reich, David Singh, Lalji Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology. Department of Mathematics Lipson, Mark Loh, Po-Ru Berger, Bonnie Most Indian groups descend from a mixture of two genetically divergent populations: Ancestral North Indians (ANI) related to Central Asians, Middle Easterners, Caucasians, and Europeans; and Ancestral South Indians (ASI) not closely related to groups outside the subcontinent. The date of mixture is unknown but has implications for understanding Indian history. We report genome-wide data from 73 groups from the Indian subcontinent and analyze linkage disequilibrium to estimate ANI-ASI mixture dates ranging from about 1,900 to 4,200 years ago. In a subset of groups, 100% of the mixture is consistent with having occurred during this period. These results show that India experienced a demographic transformation several thousand years ago, from a region in which major population mixture was common to one in which mixture even between closely related groups became rare because of a shift to endogamy. National Science Foundation (U.S.). Graduate Research Fellowship 2014-12-19T19:48:19Z 2014-12-19T19:48:19Z 2013-08 2013-05 Article http://purl.org/eprint/type/JournalArticle 00029297 1537-6605 http://hdl.handle.net/1721.1/92415 Moorjani, Priya, Kumarasamy Thangaraj, Nick Patterson, Mark Lipson, Po-Ru Loh, Periyasamy Govindaraj, Bonnie Berger, David Reich, and Lalji Singh. “Genetic Evidence for Recent Population Mixture in India.” The American Journal of Human Genetics 93, no. 3 (September 2013): 422–438. © 2013 The American Society of Human Genetics https://orcid.org/0000-0002-2724-7228 en_US http://dx.doi.org/10.1016/j.ajhg.2013.07.006 The American Journal of Human Genetics Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier Open Archive |
| spellingShingle | Moorjani, Priya Thangaraj, Kumarasamy Patterson, Nick Lipson, Mark Loh, Po-Ru Govindaraj, Periyasamy Berger, Bonnie Reich, David Singh, Lalji Genetic Evidence for Recent Population Mixture in India |
| title | Genetic Evidence for Recent Population Mixture in India |
| title_full | Genetic Evidence for Recent Population Mixture in India |
| title_fullStr | Genetic Evidence for Recent Population Mixture in India |
| title_full_unstemmed | Genetic Evidence for Recent Population Mixture in India |
| title_short | Genetic Evidence for Recent Population Mixture in India |
| title_sort | genetic evidence for recent population mixture in india |
| url | http://hdl.handle.net/1721.1/92415 https://orcid.org/0000-0002-2724-7228 |
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