Polycomb Repressive Complex 2 Regulates Lineage Fidelity during Embryonic Stem Cell Differentiation

Polycomb Repressive Complex 2 Regulates Lineage Fidelity during Embryonic Stem Cell Differentiation

Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation (H3K27me3), an epigenetic modification associated with gene repression. H3K27me3 is enriched at the promoters of a large cohort of developmental genes in embryonic stem cells (ESCs). Loss of H3K27me3 leads to a failu...

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Bibliographic Details
Main Authors:	Levine, Stuart S., Thornton, Seraphim R., Butty, Vincent L G, Boyer, Laurie Ann
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Language:	en_US
Published:	Public Library of Science 2014
Online Access:	http://hdl.handle.net/1721.1/92486 https://orcid.org/0000-0001-7099-1127 https://orcid.org/0000-0003-3491-4962

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