Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory
Pharmacological and global KO studies have worked to elucidate the function of dopamine 1-class receptors (D1Rs and D5Rs) in hippocampal-dependent learning and memory. Yet, these manipulations are unable to restrict D1R from D5R activity within hippocampal subregions. We generated mice that lack D1R...
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| Format: | Article |
| Language: | en_US |
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National Academy of Sciences (U.S.)
2015
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| Online Access: | http://hdl.handle.net/1721.1/92580 https://orcid.org/0000-0003-2839-8228 |
| _version_ | 1811075254956589056 |
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| author | Sarinana, Joshua Kitamura, Takashi Kunzler, Patrik Sultzman, Lisa Tonegawa, Susumu |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Sarinana, Joshua Kitamura, Takashi Kunzler, Patrik Sultzman, Lisa Tonegawa, Susumu |
| author_sort | Sarinana, Joshua |
| collection | MIT |
| description | Pharmacological and global KO studies have worked to elucidate the function of dopamine 1-class receptors (D1Rs and D5Rs) in hippocampal-dependent learning and memory. Yet, these manipulations are unable to restrict D1R from D5R activity within hippocampal subregions. We generated mice that lack D1Rs or D5Rs in dentate gyrus (DG) granule cells of the hippocampus. This allowed us to characterize the precise role of D1Rs and D5Rs in modulating c-Fos activity in the hippocampus and in Pavlovian fear conditioning. We demonstrate that DG D1R deletion, but not D5R deletion, increases DG granule cell baseline c-Fos activity, decreases DG and CA3 c-Fos activity in response to contextual exposure and to contextual fear conditioning, impairs contextual memory formation, and enhances generalization of the conditioned fear response. |
| first_indexed | 2024-09-23T10:03:11Z |
| format | Article |
| id | mit-1721.1/92580 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:03:11Z |
| publishDate | 2015 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/925802022-09-30T18:35:29Z Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory Sarinana, Joshua Kitamura, Takashi Kunzler, Patrik Sultzman, Lisa Tonegawa, Susumu Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory RIKEN-MIT Center for Neural Circuit Genetics Kitamura, Takashi Tonegawa, Susumu Sarinana, Joshua Kunzler, Patrik Sultzman, Lisa Pharmacological and global KO studies have worked to elucidate the function of dopamine 1-class receptors (D1Rs and D5Rs) in hippocampal-dependent learning and memory. Yet, these manipulations are unable to restrict D1R from D5R activity within hippocampal subregions. We generated mice that lack D1Rs or D5Rs in dentate gyrus (DG) granule cells of the hippocampus. This allowed us to characterize the precise role of D1Rs and D5Rs in modulating c-Fos activity in the hippocampus and in Pavlovian fear conditioning. We demonstrate that DG D1R deletion, but not D5R deletion, increases DG granule cell baseline c-Fos activity, decreases DG and CA3 c-Fos activity in response to contextual exposure and to contextual fear conditioning, impairs contextual memory formation, and enhances generalization of the conditioned fear response. Howard Hughes Medical Institute RIKEN Brain Science Institute 2015-01-05T16:03:59Z 2015-01-05T16:03:59Z 2014-05 2014-01 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/92580 Sarinana, Joshua, Takashi Kitamura, Patrik Kunzler, Lisa Sultzman, and Susumu Tonegawa. “Differential Roles of the Dopamine 1-Class Receptors, D1R and D5R, in Hippocampal Dependent Memory.” Proceedings of the National Academy of Sciences 111, no. 22 (May 19, 2014): 8245–8250. https://orcid.org/0000-0003-2839-8228 en_US http://dx.doi.org/10.1073/pnas.1407395111 Proceedings of the National Academy of Sciences of the United States of America Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) PNAS |
| spellingShingle | Sarinana, Joshua Kitamura, Takashi Kunzler, Patrik Sultzman, Lisa Tonegawa, Susumu Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory |
| title | Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory |
| title_full | Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory |
| title_fullStr | Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory |
| title_full_unstemmed | Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory |
| title_short | Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory |
| title_sort | differential roles of the dopamine 1 class receptors d1r and d5r in hippocampal dependent memory |
| url | http://hdl.handle.net/1721.1/92580 https://orcid.org/0000-0003-2839-8228 |
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