Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness
Understanding the neural basis of consciousness is fundamental to neuroscience research. Disruptions in cortico-cortical connectivity have been suggested as a primary mechanism of unconsciousness. By using a novel combination of positron emission tomography and functional magnetic resonance imaging,...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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eLife Sciences Publications, Ltd.
2015
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| Online Access: | http://hdl.handle.net/1721.1/92614 https://orcid.org/0000-0001-7067-2628 https://orcid.org/0000-0001-5651-5060 https://orcid.org/0000-0003-2668-7819 |
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| author | Akeju, Oluwaseun Catana, Ciprian Vazquez, Rafael Rhee, James Contreras Ramirez, Violeta Izquierdo-Garcia, David Arabasz, Grae Hsu, Shirley Habeeb, Kathleen Napadow, Vitaly Chonde, Daniel B. Loggia, Marco L. Hooker, Jacob M. Purdon, Patrick Lee Pavone, Kara J. Brown, Emery Neal |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Akeju, Oluwaseun Catana, Ciprian Vazquez, Rafael Rhee, James Contreras Ramirez, Violeta Izquierdo-Garcia, David Arabasz, Grae Hsu, Shirley Habeeb, Kathleen Napadow, Vitaly Chonde, Daniel B. Loggia, Marco L. Hooker, Jacob M. Purdon, Patrick Lee Pavone, Kara J. Brown, Emery Neal |
| author_sort | Akeju, Oluwaseun |
| collection | MIT |
| description | Understanding the neural basis of consciousness is fundamental to neuroscience research. Disruptions in cortico-cortical connectivity have been suggested as a primary mechanism of unconsciousness. By using a novel combination of positron emission tomography and functional magnetic resonance imaging, we studied anesthesia-induced unconsciousness and recovery using the α[subscript 2]-agonist dexmedetomidine. During unconsciousness, cerebral metabolic rate of glucose and cerebral blood flow were preferentially decreased in the thalamus, the Default Mode Network (DMN), and the bilateral Frontoparietal Networks (FPNs). Cortico-cortical functional connectivity within the DMN and FPNs was preserved. However, DMN thalamo-cortical functional connectivity was disrupted. Recovery from this state was associated with sustained reduction in cerebral blood flow and restored DMN thalamo-cortical functional connectivity. We report that loss of thalamo-cortical functional connectivity is sufficient to produce unconsciousness. |
| first_indexed | 2024-09-23T16:27:07Z |
| format | Article |
| id | mit-1721.1/92614 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:27:07Z |
| publishDate | 2015 |
| publisher | eLife Sciences Publications, Ltd. |
| record_format | dspace |
| spelling | mit-1721.1/926142022-09-29T19:52:22Z Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness Akeju, Oluwaseun Catana, Ciprian Vazquez, Rafael Rhee, James Contreras Ramirez, Violeta Izquierdo-Garcia, David Arabasz, Grae Hsu, Shirley Habeeb, Kathleen Napadow, Vitaly Chonde, Daniel B. Loggia, Marco L. Hooker, Jacob M. Purdon, Patrick Lee Pavone, Kara J. Brown, Emery Neal Massachusetts Institute of Technology. Institute for Medical Engineering & Science Martinos Imaging Center (McGovern Institute for Brain Research at MIT) Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences McGovern Institute for Brain Research at MIT Chonde, Daniel B. Loggia, Marco L. Catana, Ciprian Izquierdo-Garcia, David Arabasz, Grae Hsu, Shirley Hooker, Jacob M. Napadow, Vitaly Brown, Emery N. Purdon, Patrick Lee Understanding the neural basis of consciousness is fundamental to neuroscience research. Disruptions in cortico-cortical connectivity have been suggested as a primary mechanism of unconsciousness. By using a novel combination of positron emission tomography and functional magnetic resonance imaging, we studied anesthesia-induced unconsciousness and recovery using the α[subscript 2]-agonist dexmedetomidine. During unconsciousness, cerebral metabolic rate of glucose and cerebral blood flow were preferentially decreased in the thalamus, the Default Mode Network (DMN), and the bilateral Frontoparietal Networks (FPNs). Cortico-cortical functional connectivity within the DMN and FPNs was preserved. However, DMN thalamo-cortical functional connectivity was disrupted. Recovery from this state was associated with sustained reduction in cerebral blood flow and restored DMN thalamo-cortical functional connectivity. We report that loss of thalamo-cortical functional connectivity is sufficient to produce unconsciousness. National Institutes of Health (U.S.) (DP1-OD003646) National Institutes of Health (U.S.) (TR01-GM104948) National Institutes of Health (U.S.) (DP2-OD006454) 2015-01-05T19:42:50Z 2015-01-05T19:42:50Z 2014-11 2014-08 Article http://purl.org/eprint/type/JournalArticle 2050-084X http://hdl.handle.net/1721.1/92614 Akeju, Oluwaseun, Marco L Loggia, Ciprian Catana, Kara J Pavone, Rafael Vazquez, James Rhee, Violeta Contreras Ramirez, et al. “Disruption of Thalamic Functional Connectivity Is a Neural Correlate of Dexmedetomidine-Induced Unconsciousness.” eLife 3 (November 29, 2014). https://orcid.org/0000-0001-7067-2628 https://orcid.org/0000-0001-5651-5060 https://orcid.org/0000-0003-2668-7819 en_US http://dx.doi.org/10.7554/eLife.04499 eLife Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf eLife Sciences Publications, Ltd. eLife Sciences Publications, Ltd. |
| spellingShingle | Akeju, Oluwaseun Catana, Ciprian Vazquez, Rafael Rhee, James Contreras Ramirez, Violeta Izquierdo-Garcia, David Arabasz, Grae Hsu, Shirley Habeeb, Kathleen Napadow, Vitaly Chonde, Daniel B. Loggia, Marco L. Hooker, Jacob M. Purdon, Patrick Lee Pavone, Kara J. Brown, Emery Neal Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness |
| title | Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness |
| title_full | Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness |
| title_fullStr | Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness |
| title_full_unstemmed | Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness |
| title_short | Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness |
| title_sort | disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine induced unconsciousness |
| url | http://hdl.handle.net/1721.1/92614 https://orcid.org/0000-0001-7067-2628 https://orcid.org/0000-0001-5651-5060 https://orcid.org/0000-0003-2668-7819 |
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