Division and subtraction by distinct cortical inhibitory networks in vivo
Brain circuits process information through specialized neuronal subclasses interacting within a network. Revealing their interplay requires activating specific cells while monitoring others in a functioning circuit. Here we use a new platform for two-way light-based circuit interrogation in visual c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2015
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| Online Access: | http://hdl.handle.net/1721.1/92709 https://orcid.org/0000-0003-2442-5671 |
| _version_ | 1826210531794485248 |
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| author | Wilson, Nathan R. Runyan, Caroline A. Wang, Forea L. Sur, Mriganka |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Wilson, Nathan R. Runyan, Caroline A. Wang, Forea L. Sur, Mriganka |
| author_sort | Wilson, Nathan R. |
| collection | MIT |
| description | Brain circuits process information through specialized neuronal subclasses interacting within a network. Revealing their interplay requires activating specific cells while monitoring others in a functioning circuit. Here we use a new platform for two-way light-based circuit interrogation in visual cortex in vivo to show the computational implications of modulating different subclasses of inhibitory neurons during sensory processing. We find that soma-targeting, parvalbumin-expressing (PV) neurons principally divide responses but preserve stimulus selectivity, whereas dendrite-targeting, somatostatin-expressing (SOM) neurons principally subtract from excitatory responses and sharpen selectivity. Visualized in vivo cell-attached recordings show that division by PV neurons alters response gain, whereas subtraction by SOM neurons shifts response levels. Finally, stimulating identified neurons while scanning many target cells reveals that single PV and SOM neurons functionally impact only specific subsets of neurons in their projection fields. These findings provide direct evidence that inhibitory neuronal subclasses have distinct and complementary roles in cortical computations. |
| first_indexed | 2024-09-23T14:51:08Z |
| format | Article |
| id | mit-1721.1/92709 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:51:08Z |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/927092022-10-01T22:55:16Z Division and subtraction by distinct cortical inhibitory networks in vivo Wilson, Nathan R. Runyan, Caroline A. Wang, Forea L. Sur, Mriganka Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Wilson, Nathan R. Runyan, Caroline A. Wang, Forea L. Sur, Mriganka Brain circuits process information through specialized neuronal subclasses interacting within a network. Revealing their interplay requires activating specific cells while monitoring others in a functioning circuit. Here we use a new platform for two-way light-based circuit interrogation in visual cortex in vivo to show the computational implications of modulating different subclasses of inhibitory neurons during sensory processing. We find that soma-targeting, parvalbumin-expressing (PV) neurons principally divide responses but preserve stimulus selectivity, whereas dendrite-targeting, somatostatin-expressing (SOM) neurons principally subtract from excitatory responses and sharpen selectivity. Visualized in vivo cell-attached recordings show that division by PV neurons alters response gain, whereas subtraction by SOM neurons shifts response levels. Finally, stimulating identified neurons while scanning many target cells reveals that single PV and SOM neurons functionally impact only specific subsets of neurons in their projection fields. These findings provide direct evidence that inhibitory neuronal subclasses have distinct and complementary roles in cortical computations. National Institutes of Health (U.S.) (Postdoctoral Fellowship) Simons Foundation (Postdoctoral Fellowship) National Institutes of Health (U.S.) (Predoctoral Fellowship) 2015-01-06T18:20:57Z 2015-01-06T18:20:57Z 2012-08 2011-12 Article http://purl.org/eprint/type/JournalArticle 0028-0836 1476-4687 http://hdl.handle.net/1721.1/92709 Wilson, Nathan R., Caroline A. Runyan, Forea L. Wang, and Mriganka Sur. “Division and Subtraction by Distinct Cortical Inhibitory Networks in Vivo.” Nature 488, no. 7411 (August 8, 2012): 343–348. https://orcid.org/0000-0003-2442-5671 en_US http://dx.doi.org/10.1038/nature11347 Nature Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Nature Publishing Group PMC |
| spellingShingle | Wilson, Nathan R. Runyan, Caroline A. Wang, Forea L. Sur, Mriganka Division and subtraction by distinct cortical inhibitory networks in vivo |
| title | Division and subtraction by distinct cortical inhibitory networks in vivo |
| title_full | Division and subtraction by distinct cortical inhibitory networks in vivo |
| title_fullStr | Division and subtraction by distinct cortical inhibitory networks in vivo |
| title_full_unstemmed | Division and subtraction by distinct cortical inhibitory networks in vivo |
| title_short | Division and subtraction by distinct cortical inhibitory networks in vivo |
| title_sort | division and subtraction by distinct cortical inhibitory networks in vivo |
| url | http://hdl.handle.net/1721.1/92709 https://orcid.org/0000-0003-2442-5671 |
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