miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
Using quantitative analyses, we identified microRNAs (miRNAs) that were abundantly expressed in visual cortex and that responded to dark rearing and/or monocular deprivation. The most substantially altered miRNA, miR-132, was rapidly upregulated after eye opening and was delayed by dark rearing. In...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2015
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| Online Access: | http://hdl.handle.net/1721.1/92819 https://orcid.org/0000-0003-2442-5671 https://orcid.org/0000-0001-9730-6636 |
| _version_ | 1826205715405996032 |
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| author | Mellios, Nikolaos Sugihara, Hiroki Castro, Jorge Banerjee, Abhishek Le, Chuong N. Kumar, Arooshi R. Crawford, Benjamin Strathmann, Julia Tropea, Daniela Edbauer, Dieter Sur, Mriganka Levine, Stuart S. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Mellios, Nikolaos Sugihara, Hiroki Castro, Jorge Banerjee, Abhishek Le, Chuong N. Kumar, Arooshi R. Crawford, Benjamin Strathmann, Julia Tropea, Daniela Edbauer, Dieter Sur, Mriganka Levine, Stuart S. |
| author_sort | Mellios, Nikolaos |
| collection | MIT |
| description | Using quantitative analyses, we identified microRNAs (miRNAs) that were abundantly expressed in visual cortex and that responded to dark rearing and/or monocular deprivation. The most substantially altered miRNA, miR-132, was rapidly upregulated after eye opening and was delayed by dark rearing. In vivo inhibition of miR-132 in mice prevented ocular dominance plasticity in identified neurons following monocular deprivation and affected the maturation of dendritic spines, demonstrating its critical role in the plasticity of visual cortex circuits. |
| first_indexed | 2024-09-23T13:17:27Z |
| format | Article |
| id | mit-1721.1/92819 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:17:27Z |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/928192021-09-13T13:57:46Z miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity Mellios, Nikolaos Sugihara, Hiroki Castro, Jorge Banerjee, Abhishek Le, Chuong N. Kumar, Arooshi R. Crawford, Benjamin Strathmann, Julia Tropea, Daniela Edbauer, Dieter Sur, Mriganka Levine, Stuart S. Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Mellios, Nikolaos Sugihara, Hiroki Castro, Jorge Banerjee, Abhishek Le, Chuong N. Kumar, Arooshi R. Crawford, Benjamin Tropea, Daniela Levine, Stuart S. Sur, Mriganka Using quantitative analyses, we identified microRNAs (miRNAs) that were abundantly expressed in visual cortex and that responded to dark rearing and/or monocular deprivation. The most substantially altered miRNA, miR-132, was rapidly upregulated after eye opening and was delayed by dark rearing. In vivo inhibition of miR-132 in mice prevented ocular dominance plasticity in identified neurons following monocular deprivation and affected the maturation of dendritic spines, demonstrating its critical role in the plasticity of visual cortex circuits. National Eye Institute (Ruth L. Kirschstein Postdoctoral Fellowship 1F32EY020066-01) Simons Foundation (Postdoctoral Fellowship) National Institutes of Health (U.S.) (EY017098) National Institutes of Health (U.S.) (EY007023) 2015-01-13T15:49:51Z 2015-01-13T15:49:51Z 2011-09 2011-05 Article http://purl.org/eprint/type/JournalArticle 1097-6256 1546-1726 http://hdl.handle.net/1721.1/92819 Mellios, Nikolaos, Hiroki Sugihara, Jorge Castro, Abhishek Banerjee, Chuong Le, Arooshi Kumar, Benjamin Crawford, et al. “miR-132, an Experience-Dependent microRNA, Is Essential for Visual Cortex Plasticity.” Nat Neurosci 14, no. 10 (September 4, 2011): 1240–1242. https://orcid.org/0000-0003-2442-5671 https://orcid.org/0000-0001-9730-6636 en_US http://dx.doi.org/10.1038/nn.2909 Nature Neuroscience Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Nature Publishing Group PMC |
| spellingShingle | Mellios, Nikolaos Sugihara, Hiroki Castro, Jorge Banerjee, Abhishek Le, Chuong N. Kumar, Arooshi R. Crawford, Benjamin Strathmann, Julia Tropea, Daniela Edbauer, Dieter Sur, Mriganka Levine, Stuart S. miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity |
| title | miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity |
| title_full | miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity |
| title_fullStr | miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity |
| title_full_unstemmed | miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity |
| title_short | miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity |
| title_sort | mir 132 an experience dependent microrna is essential for visual cortex plasticity |
| url | http://hdl.handle.net/1721.1/92819 https://orcid.org/0000-0003-2442-5671 https://orcid.org/0000-0001-9730-6636 |
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