Input-specific control of reward and aversion in the ventral tegmental area
Ventral tegmental area (VTA) dopamine neurons have important roles in adaptive and pathological brain functions related to reward and motivation. However, it is unknown whether subpopulations of VTA dopamine neurons participate in distinct circuits that encode different motivational signatures, and...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2015
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| Online Access: | http://hdl.handle.net/1721.1/92891 |
| _version_ | 1811074487672635392 |
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| author | Tye, Kay Lammel, Stephan Lim, Byung Kook Ran, Chen Huang, Kee Wui Betley, Michael J. Malenka, Robert C. Deisseroth, Karl |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Tye, Kay Lammel, Stephan Lim, Byung Kook Ran, Chen Huang, Kee Wui Betley, Michael J. Malenka, Robert C. Deisseroth, Karl |
| author_sort | Tye, Kay |
| collection | MIT |
| description | Ventral tegmental area (VTA) dopamine neurons have important roles in adaptive and pathological brain functions related to reward and motivation. However, it is unknown whether subpopulations of VTA dopamine neurons participate in distinct circuits that encode different motivational signatures, and whether inputs to the VTA differentially modulate such circuits. Here we show that, because of differences in synaptic connectivity, activation of inputs to the VTA from the laterodorsal tegmentum and the lateral habenula elicit reward and aversion in mice, respectively. Laterodorsal tegmentum neurons preferentially synapse on dopamine neurons projecting to the nucleus accumbens lateral shell, whereas lateral habenula neurons synapse primarily on dopamine neurons projecting to the medial prefrontal cortex as well as on GABAergic (γ-aminobutyric-acid-containing) neurons in the rostromedial tegmental nucleus. These results establish that distinct VTA circuits generate reward and aversion, and thereby provide a new framework for understanding the circuit basis of adaptive and pathological motivated behaviours. |
| first_indexed | 2024-09-23T09:50:13Z |
| format | Article |
| id | mit-1721.1/92891 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:50:13Z |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/928912022-09-26T14:00:46Z Input-specific control of reward and aversion in the ventral tegmental area Tye, Kay Lammel, Stephan Lim, Byung Kook Ran, Chen Huang, Kee Wui Betley, Michael J. Malenka, Robert C. Deisseroth, Karl Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Tye, Kay Ventral tegmental area (VTA) dopamine neurons have important roles in adaptive and pathological brain functions related to reward and motivation. However, it is unknown whether subpopulations of VTA dopamine neurons participate in distinct circuits that encode different motivational signatures, and whether inputs to the VTA differentially modulate such circuits. Here we show that, because of differences in synaptic connectivity, activation of inputs to the VTA from the laterodorsal tegmentum and the lateral habenula elicit reward and aversion in mice, respectively. Laterodorsal tegmentum neurons preferentially synapse on dopamine neurons projecting to the nucleus accumbens lateral shell, whereas lateral habenula neurons synapse primarily on dopamine neurons projecting to the medial prefrontal cortex as well as on GABAergic (γ-aminobutyric-acid-containing) neurons in the rostromedial tegmental nucleus. These results establish that distinct VTA circuits generate reward and aversion, and thereby provide a new framework for understanding the circuit basis of adaptive and pathological motivated behaviours. National Institutes of Health (U.S.) (Grant NIH NS069375) JPB Foundation National Institute of Mental Health (U.S.) 2015-01-15T18:15:28Z 2015-01-15T18:15:28Z 2012-10 2012-04 Article http://purl.org/eprint/type/JournalArticle 0028-0836 1476-4687 http://hdl.handle.net/1721.1/92891 Lammel, Stephan, Byung Kook Lim, Chen Ran, Kee Wui Huang, Michael J. Betley, Kay M. Tye, Karl Deisseroth, and Robert C. Malenka. “Input-Specific Control of Reward and Aversion in the Ventral Tegmental Area.” Nature 491, no. 7423 (October 14, 2012): 212–217. en_US http://dx.doi.org/10.1038/nature11527 Nature Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Nature Publishing Group PMC |
| spellingShingle | Tye, Kay Lammel, Stephan Lim, Byung Kook Ran, Chen Huang, Kee Wui Betley, Michael J. Malenka, Robert C. Deisseroth, Karl Input-specific control of reward and aversion in the ventral tegmental area |
| title | Input-specific control of reward and aversion in the ventral tegmental area |
| title_full | Input-specific control of reward and aversion in the ventral tegmental area |
| title_fullStr | Input-specific control of reward and aversion in the ventral tegmental area |
| title_full_unstemmed | Input-specific control of reward and aversion in the ventral tegmental area |
| title_short | Input-specific control of reward and aversion in the ventral tegmental area |
| title_sort | input specific control of reward and aversion in the ventral tegmental area |
| url | http://hdl.handle.net/1721.1/92891 |
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