RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs
The rugged nature of the RNA structural free energy landscape allows cellular RNAs to respond to environmental conditions or fluctuating levels of effector molecules by undergoing dynamic conformational changes that switch on or off activities such as catalysis, transcription or translation. Infecti...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/92952 https://orcid.org/0000-0002-9387-8212 |
| _version_ | 1811093119606718464 |
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| author | Simon, Anne E. Gehrke, Lee |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Simon, Anne E. Gehrke, Lee |
| author_sort | Simon, Anne E. |
| collection | MIT |
| description | The rugged nature of the RNA structural free energy landscape allows cellular RNAs to respond to environmental conditions or fluctuating levels of effector molecules by undergoing dynamic conformational changes that switch on or off activities such as catalysis, transcription or translation. Infectious RNAs must also temporally control incompatible activities and rapidly complete their life cycle before being targeted by cellular defenses. Viral genomic RNAs must switch between translation and replication, and untranslated subviral RNAs must control other activities such as RNA editing or self-cleavage. Unlike well characterized riboswitches in cellular RNAs, the control of infectious RNA activities by altering the configuration of functional RNA domains has only recently been recognized. In this review, we will present some of these molecular rearrangements found in RNA viruses, viroids and virus-associated RNAs, relating how these dynamic regions were discovered, the activities that might be regulated, and what factors or conditions might cause a switch between conformations. |
| first_indexed | 2024-09-23T15:40:01Z |
| format | Article |
| id | mit-1721.1/92952 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:40:01Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/929522022-10-02T03:14:31Z RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs Simon, Anne E. Gehrke, Lee Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Gehrke, Lee The rugged nature of the RNA structural free energy landscape allows cellular RNAs to respond to environmental conditions or fluctuating levels of effector molecules by undergoing dynamic conformational changes that switch on or off activities such as catalysis, transcription or translation. Infectious RNAs must also temporally control incompatible activities and rapidly complete their life cycle before being targeted by cellular defenses. Viral genomic RNAs must switch between translation and replication, and untranslated subviral RNAs must control other activities such as RNA editing or self-cleavage. Unlike well characterized riboswitches in cellular RNAs, the control of infectious RNA activities by altering the configuration of functional RNA domains has only recently been recognized. In this review, we will present some of these molecular rearrangements found in RNA viruses, viroids and virus-associated RNAs, relating how these dynamic regions were discovered, the activities that might be regulated, and what factors or conditions might cause a switch between conformations. 2015-01-20T14:14:24Z 2015-01-20T14:14:24Z 2009-06 2009-05 Article http://purl.org/eprint/type/JournalArticle 18749399 http://hdl.handle.net/1721.1/92952 Simon, Anne E., and Lee Gehrke. “RNA Conformational Changes in the Life Cycles of RNA Viruses, Viroids, and Virus-Associated RNAs.” Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1789.9-10 (2009): 571–583. https://orcid.org/0000-0002-9387-8212 en_US http://dx.doi.org/10.1016/j.bbagrm.2009.05.005 Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Simon, Anne E. Gehrke, Lee RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs |
| title | RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs |
| title_full | RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs |
| title_fullStr | RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs |
| title_full_unstemmed | RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs |
| title_short | RNA conformational changes in the life cycles of RNA viruses, viroids, and virus-associated RNAs |
| title_sort | rna conformational changes in the life cycles of rna viruses viroids and virus associated rnas |
| url | http://hdl.handle.net/1721.1/92952 https://orcid.org/0000-0002-9387-8212 |
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