Atomic-Scale Nuclear Spin Imaging Using Quantum-Assisted Sensors in Diamond
Nuclear spin imaging at the atomic level is essential for the understanding of fundamental biological phenomena and for applications such as drug discovery. The advent of novel nanoscale sensors promises to achieve the long-standing goal of single-protein, high spatial-resolution structure determina...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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American Physical Society
2015
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| Online Access: | http://hdl.handle.net/1721.1/92977 https://orcid.org/0000-0003-0544-5263 https://orcid.org/0000-0003-3207-594X |
| _version_ | 1826203309090799616 |
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| author | Ajoy, Ashok Bissbort, U Lukin, M. D. Walsworth, R. L. Cappellaro, Paola |
| author2 | Massachusetts Institute of Technology. Department of Nuclear Science and Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Nuclear Science and Engineering Ajoy, Ashok Bissbort, U Lukin, M. D. Walsworth, R. L. Cappellaro, Paola |
| author_sort | Ajoy, Ashok |
| collection | MIT |
| description | Nuclear spin imaging at the atomic level is essential for the understanding of fundamental biological phenomena and for applications such as drug discovery. The advent of novel nanoscale sensors promises to achieve the long-standing goal of single-protein, high spatial-resolution structure determination under ambient conditions. In particular, quantum sensors based on the spin-dependent photoluminescence of nitrogen-vacancy (NV) centers in diamond have recently been used to detect nanoscale ensembles of external nuclear spins. While NV sensitivity is approaching single-spin levels, extracting relevant information from a very complex structure is a further challenge since it requires not only the ability to sense the magnetic field of an isolated nuclear spin but also to achieve atomic-scale spatial resolution. Here, we propose a method that, by exploiting the coupling of the NV center to an intrinsic quantum memory associated with the nitrogen nuclear spin, can reach a tenfold improvement in spatial resolution, down to atomic scales. The spatial resolution enhancement is achieved through coherent control of the sensor spin, which creates a dynamic frequency filter selecting only a few nuclear spins at a time. We propose and analyze a protocol that would allow not only sensing individual spins in a complex biomolecule, but also unraveling couplings among them, thus elucidating local characteristics of the molecule structure. |
| first_indexed | 2024-09-23T12:34:54Z |
| format | Article |
| id | mit-1721.1/92977 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:34:54Z |
| publishDate | 2015 |
| publisher | American Physical Society |
| record_format | dspace |
| spelling | mit-1721.1/929772022-09-28T08:44:59Z Atomic-Scale Nuclear Spin Imaging Using Quantum-Assisted Sensors in Diamond Ajoy, Ashok Bissbort, U Lukin, M. D. Walsworth, R. L. Cappellaro, Paola Massachusetts Institute of Technology. Department of Nuclear Science and Engineering Massachusetts Institute of Technology. Research Laboratory of Electronics Ajoy, Ashok Cappellaro, Paola Bissbort, U. Nuclear spin imaging at the atomic level is essential for the understanding of fundamental biological phenomena and for applications such as drug discovery. The advent of novel nanoscale sensors promises to achieve the long-standing goal of single-protein, high spatial-resolution structure determination under ambient conditions. In particular, quantum sensors based on the spin-dependent photoluminescence of nitrogen-vacancy (NV) centers in diamond have recently been used to detect nanoscale ensembles of external nuclear spins. While NV sensitivity is approaching single-spin levels, extracting relevant information from a very complex structure is a further challenge since it requires not only the ability to sense the magnetic field of an isolated nuclear spin but also to achieve atomic-scale spatial resolution. Here, we propose a method that, by exploiting the coupling of the NV center to an intrinsic quantum memory associated with the nitrogen nuclear spin, can reach a tenfold improvement in spatial resolution, down to atomic scales. The spatial resolution enhancement is achieved through coherent control of the sensor spin, which creates a dynamic frequency filter selecting only a few nuclear spins at a time. We propose and analyze a protocol that would allow not only sensing individual spins in a complex biomolecule, but also unraveling couplings among them, thus elucidating local characteristics of the molecule structure. United States. Army Research Office. Multidisciplinary University Research Initiative (Grant W911NF-11-1-0400) United States. Defense Advanced Research Projects Agency. Quantum-Assisted Sensing and Readout (QuASAR) Program 2015-01-20T16:15:53Z 2015-01-20T16:15:53Z 2015-01 2014-08 2015-01-07T23:00:10Z Article http://purl.org/eprint/type/JournalArticle 2160-3308 http://hdl.handle.net/1721.1/92977 Ajoy, A. et al. “Atomic-Scale Nuclear Spin Imaging Using Quantum-Assisted Sensors in Diamond.” Physical Review X 5.1 (2015): 011001-1-011001-11. https://orcid.org/0000-0003-0544-5263 https://orcid.org/0000-0003-3207-594X en http://dx.doi.org/10.1103/PhysRevX.5.011001 Physical Review X Creative Commons Attribution http://creativecommons.org/licenses/by/3.0 authors application/pdf American Physical Society American Physical Society |
| spellingShingle | Ajoy, Ashok Bissbort, U Lukin, M. D. Walsworth, R. L. Cappellaro, Paola Atomic-Scale Nuclear Spin Imaging Using Quantum-Assisted Sensors in Diamond |
| title | Atomic-Scale Nuclear Spin Imaging Using Quantum-Assisted Sensors in Diamond |
| title_full | Atomic-Scale Nuclear Spin Imaging Using Quantum-Assisted Sensors in Diamond |
| title_fullStr | Atomic-Scale Nuclear Spin Imaging Using Quantum-Assisted Sensors in Diamond |
| title_full_unstemmed | Atomic-Scale Nuclear Spin Imaging Using Quantum-Assisted Sensors in Diamond |
| title_short | Atomic-Scale Nuclear Spin Imaging Using Quantum-Assisted Sensors in Diamond |
| title_sort | atomic scale nuclear spin imaging using quantum assisted sensors in diamond |
| url | http://hdl.handle.net/1721.1/92977 https://orcid.org/0000-0003-0544-5263 https://orcid.org/0000-0003-3207-594X |
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