Rapid Wolff–Kishner reductions in a silicon carbide microreactor

Wolff–Kishner reductions are performed in a novel silicon carbide microreactor. Greatly reduced reaction times and safer operation are achieved, giving high yields without requiring a large excess of hydrazine. The corrosion resistance of silicon carbide avoids the problematic reactor compatibility...

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Main Authors: Newman, Stephen G., Gu, Lei, Lesniak, Christoph, Victor, Georg, Meschke, Frank, Abahmane, Lahbib, Jensen, Klavs F.
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: Royal Society of Chemistry 2015
Online Access:http://hdl.handle.net/1721.1/93163
https://orcid.org/0000-0001-7192-580X
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author Newman, Stephen G.
Gu, Lei
Lesniak, Christoph
Victor, Georg
Meschke, Frank
Abahmane, Lahbib
Jensen, Klavs F.
author2 Massachusetts Institute of Technology. Department of Chemical Engineering
author_facet Massachusetts Institute of Technology. Department of Chemical Engineering
Newman, Stephen G.
Gu, Lei
Lesniak, Christoph
Victor, Georg
Meschke, Frank
Abahmane, Lahbib
Jensen, Klavs F.
author_sort Newman, Stephen G.
collection MIT
description Wolff–Kishner reductions are performed in a novel silicon carbide microreactor. Greatly reduced reaction times and safer operation are achieved, giving high yields without requiring a large excess of hydrazine. The corrosion resistance of silicon carbide avoids the problematic reactor compatibility issues that arise when Wolff–Kishner reductions are done in glass or stainless steel reactors. With only nitrogen gas and water as by-products, this opens the possibility of performing selective, large scale ketone reductions without the generation of hazardous waste streams.
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spelling mit-1721.1/931632022-09-30T21:38:14Z Rapid Wolff–Kishner reductions in a silicon carbide microreactor Newman, Stephen G. Gu, Lei Lesniak, Christoph Victor, Georg Meschke, Frank Abahmane, Lahbib Jensen, Klavs F. Massachusetts Institute of Technology. Department of Chemical Engineering Jensen, Klavs F. Newman, Stephen G. Gu, Lei Jensen, Klavs F. Wolff–Kishner reductions are performed in a novel silicon carbide microreactor. Greatly reduced reaction times and safer operation are achieved, giving high yields without requiring a large excess of hydrazine. The corrosion resistance of silicon carbide avoids the problematic reactor compatibility issues that arise when Wolff–Kishner reductions are done in glass or stainless steel reactors. With only nitrogen gas and water as by-products, this opens the possibility of performing selective, large scale ketone reductions without the generation of hazardous waste streams. Novartis-MIT Center for Continuous Manufacturing Natural Sciences and Engineering Research Council of Canada (post-doctoral fellowship) 2015-01-22T21:34:56Z 2015-01-22T21:34:56Z 2014 2013-09 Article http://purl.org/eprint/type/JournalArticle 1463-9262 1463-9270 http://hdl.handle.net/1721.1/93163 Newman, Stephen G., Lei Gu, Christoph Lesniak, Georg Victor, Frank Meschke, Lahbib Abahmane, and Klavs F. Jensen. “Rapid Wolff–Kishner Reductions in a Silicon Carbide Microreactor.” Green Chemistry 16, no. 1 (2013): 176. https://orcid.org/0000-0001-7192-580X en_US http://dx.doi.org/10.1039/c3gc41942h Green Chemistry Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Royal Society of Chemistry Prof. Jensen via Erja Kajosalo
spellingShingle Newman, Stephen G.
Gu, Lei
Lesniak, Christoph
Victor, Georg
Meschke, Frank
Abahmane, Lahbib
Jensen, Klavs F.
Rapid Wolff–Kishner reductions in a silicon carbide microreactor
title Rapid Wolff–Kishner reductions in a silicon carbide microreactor
title_full Rapid Wolff–Kishner reductions in a silicon carbide microreactor
title_fullStr Rapid Wolff–Kishner reductions in a silicon carbide microreactor
title_full_unstemmed Rapid Wolff–Kishner reductions in a silicon carbide microreactor
title_short Rapid Wolff–Kishner reductions in a silicon carbide microreactor
title_sort rapid wolff kishner reductions in a silicon carbide microreactor
url http://hdl.handle.net/1721.1/93163
https://orcid.org/0000-0001-7192-580X
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