Rapid Wolff–Kishner reductions in a silicon carbide microreactor
Wolff–Kishner reductions are performed in a novel silicon carbide microreactor. Greatly reduced reaction times and safer operation are achieved, giving high yields without requiring a large excess of hydrazine. The corrosion resistance of silicon carbide avoids the problematic reactor compatibility...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Royal Society of Chemistry
2015
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| Online Access: | http://hdl.handle.net/1721.1/93163 https://orcid.org/0000-0001-7192-580X |
| _version_ | 1826196653975011328 |
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| author | Newman, Stephen G. Gu, Lei Lesniak, Christoph Victor, Georg Meschke, Frank Abahmane, Lahbib Jensen, Klavs F. |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Newman, Stephen G. Gu, Lei Lesniak, Christoph Victor, Georg Meschke, Frank Abahmane, Lahbib Jensen, Klavs F. |
| author_sort | Newman, Stephen G. |
| collection | MIT |
| description | Wolff–Kishner reductions are performed in a novel silicon carbide microreactor. Greatly reduced reaction times and safer operation are achieved, giving high yields without requiring a large excess of hydrazine. The corrosion resistance of silicon carbide avoids the problematic reactor compatibility issues that arise when Wolff–Kishner reductions are done in glass or stainless steel reactors. With only nitrogen gas and water as by-products, this opens the possibility of performing selective, large scale ketone reductions without the generation of hazardous waste streams. |
| first_indexed | 2024-09-23T10:32:42Z |
| format | Article |
| id | mit-1721.1/93163 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:32:42Z |
| publishDate | 2015 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | mit-1721.1/931632022-09-30T21:38:14Z Rapid Wolff–Kishner reductions in a silicon carbide microreactor Newman, Stephen G. Gu, Lei Lesniak, Christoph Victor, Georg Meschke, Frank Abahmane, Lahbib Jensen, Klavs F. Massachusetts Institute of Technology. Department of Chemical Engineering Jensen, Klavs F. Newman, Stephen G. Gu, Lei Jensen, Klavs F. Wolff–Kishner reductions are performed in a novel silicon carbide microreactor. Greatly reduced reaction times and safer operation are achieved, giving high yields without requiring a large excess of hydrazine. The corrosion resistance of silicon carbide avoids the problematic reactor compatibility issues that arise when Wolff–Kishner reductions are done in glass or stainless steel reactors. With only nitrogen gas and water as by-products, this opens the possibility of performing selective, large scale ketone reductions without the generation of hazardous waste streams. Novartis-MIT Center for Continuous Manufacturing Natural Sciences and Engineering Research Council of Canada (post-doctoral fellowship) 2015-01-22T21:34:56Z 2015-01-22T21:34:56Z 2014 2013-09 Article http://purl.org/eprint/type/JournalArticle 1463-9262 1463-9270 http://hdl.handle.net/1721.1/93163 Newman, Stephen G., Lei Gu, Christoph Lesniak, Georg Victor, Frank Meschke, Lahbib Abahmane, and Klavs F. Jensen. “Rapid Wolff–Kishner Reductions in a Silicon Carbide Microreactor.” Green Chemistry 16, no. 1 (2013): 176. https://orcid.org/0000-0001-7192-580X en_US http://dx.doi.org/10.1039/c3gc41942h Green Chemistry Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Royal Society of Chemistry Prof. Jensen via Erja Kajosalo |
| spellingShingle | Newman, Stephen G. Gu, Lei Lesniak, Christoph Victor, Georg Meschke, Frank Abahmane, Lahbib Jensen, Klavs F. Rapid Wolff–Kishner reductions in a silicon carbide microreactor |
| title | Rapid Wolff–Kishner reductions in a silicon carbide microreactor |
| title_full | Rapid Wolff–Kishner reductions in a silicon carbide microreactor |
| title_fullStr | Rapid Wolff–Kishner reductions in a silicon carbide microreactor |
| title_full_unstemmed | Rapid Wolff–Kishner reductions in a silicon carbide microreactor |
| title_short | Rapid Wolff–Kishner reductions in a silicon carbide microreactor |
| title_sort | rapid wolff kishner reductions in a silicon carbide microreactor |
| url | http://hdl.handle.net/1721.1/93163 https://orcid.org/0000-0001-7192-580X |
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