Two-Photon Oxygen Sensing with Quantum Dot-Porphyrin Conjugates
Supramolecular assemblies of a quantum dot (QD) associated to palladium(II) porphyrins have been developed to detect oxygen (pO[subscript 2]) in organic solvents. Palladium porphyrins are sensitive in the 0–160 Torr range, making them ideal phosphors for in vivo biological oxygen quantification. Por...
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| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2015
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| Online Access: | http://hdl.handle.net/1721.1/93246 https://orcid.org/0000-0003-2220-4365 |
| _version_ | 1826207597427949568 |
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| author | Lemon, Christopher M. Karnas, Elizabeth Bawendi, Moungi G. Nocera, Daniel G. |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Lemon, Christopher M. Karnas, Elizabeth Bawendi, Moungi G. Nocera, Daniel G. |
| author_sort | Lemon, Christopher M. |
| collection | MIT |
| description | Supramolecular assemblies of a quantum dot (QD) associated to palladium(II) porphyrins have been developed to detect oxygen (pO[subscript 2]) in organic solvents. Palladium porphyrins are sensitive in the 0–160 Torr range, making them ideal phosphors for in vivo biological oxygen quantification. Porphyrins with meso pyridyl substituents bind to the surface of the QD to produce self-assembled nanosensors. Appreciable overlap between QD emission and porphyrin absorption features results in efficient Forster resonance energy transfer (FRET) for signal transduction in these sensors. The QD serves as a photon antenna, enhancing porphyrin emission under both one- and two-photon excitation, demonstrating that QD-palladium porphyrin conjugates may be used for oxygen sensing over physiological oxygen ranges. |
| first_indexed | 2024-09-23T13:52:21Z |
| format | Article |
| id | mit-1721.1/93246 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:52:21Z |
| publishDate | 2015 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/932462022-10-01T17:38:14Z Two-Photon Oxygen Sensing with Quantum Dot-Porphyrin Conjugates Lemon, Christopher M. Karnas, Elizabeth Bawendi, Moungi G. Nocera, Daniel G. Massachusetts Institute of Technology. Department of Chemistry Lemon, Christopher M. Karnas, Elizabeth Bawendi, Moungi G. Supramolecular assemblies of a quantum dot (QD) associated to palladium(II) porphyrins have been developed to detect oxygen (pO[subscript 2]) in organic solvents. Palladium porphyrins are sensitive in the 0–160 Torr range, making them ideal phosphors for in vivo biological oxygen quantification. Porphyrins with meso pyridyl substituents bind to the surface of the QD to produce self-assembled nanosensors. Appreciable overlap between QD emission and porphyrin absorption features results in efficient Forster resonance energy transfer (FRET) for signal transduction in these sensors. The QD serves as a photon antenna, enhancing porphyrin emission under both one- and two-photon excitation, demonstrating that QD-palladium porphyrin conjugates may be used for oxygen sensing over physiological oxygen ranges. National Cancer Institute (U.S.) (Grant R01-CA126642) National Science Foundation (U.S.). Graduate Research Fellowship 2015-01-30T20:07:15Z 2015-01-30T20:07:15Z 2013-08 2013-05 Article http://purl.org/eprint/type/JournalArticle 0020-1669 1520-510X http://hdl.handle.net/1721.1/93246 Lemon, Christopher M., Elizabeth Karnas, Moungi G. Bawendi, and Daniel G. Nocera. “Two-Photon Oxygen Sensing with Quantum Dot-Porphyrin Conjugates.” Inorg. Chem. 52, no. 18 (September 16, 2013): 10394–10406. https://orcid.org/0000-0003-2220-4365 en_US http://dx.doi.org/10.1021/ic4011168 Inorganic Chemistry Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Lemon, Christopher M. Karnas, Elizabeth Bawendi, Moungi G. Nocera, Daniel G. Two-Photon Oxygen Sensing with Quantum Dot-Porphyrin Conjugates |
| title | Two-Photon Oxygen Sensing with Quantum Dot-Porphyrin Conjugates |
| title_full | Two-Photon Oxygen Sensing with Quantum Dot-Porphyrin Conjugates |
| title_fullStr | Two-Photon Oxygen Sensing with Quantum Dot-Porphyrin Conjugates |
| title_full_unstemmed | Two-Photon Oxygen Sensing with Quantum Dot-Porphyrin Conjugates |
| title_short | Two-Photon Oxygen Sensing with Quantum Dot-Porphyrin Conjugates |
| title_sort | two photon oxygen sensing with quantum dot porphyrin conjugates |
| url | http://hdl.handle.net/1721.1/93246 https://orcid.org/0000-0003-2220-4365 |
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