Differential requirement for NMDAR activity in SAP97 -mediated regulation of the number and strength of glutamatergic AMPAR-containing synapses

PSD-95-like, disc-large (DLG) family membrane-associated guanylate kinase proteins (PSD/DLG-MAGUKs) are essential for regulating synaptic AMPA receptor (AMPAR) function and activity-dependent trafficking of AMPARs. Using a molecular replacement strategy to replace endogenous PSD-95 with SAP97β, we s...

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Bibliographic Details
Main Authors: Liu, Mingna, Lewis, Laura D., Shi, Rebecca D., Xu, Weifeng, Brown, Emery Neal
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: American Physiological Society 2015
Online Access:http://hdl.handle.net/1721.1/93904
https://orcid.org/0000-0001-6888-5448
https://orcid.org/0000-0003-2668-7819
https://orcid.org/0000-0001-7060-0288
https://orcid.org/0000-0003-0096-2288