Mild and General Palladium-Catalyzed Synthesis of Methyl Aryl Ethers Enabled by the Use of a Palladacycle Precatalyst
A general method for the Pd-catalyzed coupling of methanol with (hetero)aryl halides is described. The reactions proceed under mild conditions with a wide range of aryl and heteroaryl halides to give methyl aryl ethers in high yield.
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2015
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| Online Access: | http://hdl.handle.net/1721.1/93912 https://orcid.org/0000-0003-3875-4775 |
| _version_ | 1826210331390640128 |
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| author | Cheung, Chi Wai Buchwald, Stephen Leffler |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Cheung, Chi Wai Buchwald, Stephen Leffler |
| author_sort | Cheung, Chi Wai |
| collection | MIT |
| description | A general method for the Pd-catalyzed coupling of methanol with (hetero)aryl halides is described. The reactions proceed under mild conditions with a wide range of aryl and heteroaryl halides to give methyl aryl ethers in high yield. |
| first_indexed | 2024-09-23T14:48:07Z |
| format | Article |
| id | mit-1721.1/93912 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:48:07Z |
| publishDate | 2015 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/939122022-09-29T10:38:14Z Mild and General Palladium-Catalyzed Synthesis of Methyl Aryl Ethers Enabled by the Use of a Palladacycle Precatalyst Cheung, Chi Wai Buchwald, Stephen Leffler Massachusetts Institute of Technology. Department of Chemistry Cheung, Chi Wai Buchwald, Stephen Leffler A general method for the Pd-catalyzed coupling of methanol with (hetero)aryl halides is described. The reactions proceed under mild conditions with a wide range of aryl and heteroaryl halides to give methyl aryl ethers in high yield. National Institutes of Health (U.S.) (GM58160) Croucher Foundation (Postdoctoral Fellowship) 2015-02-06T19:50:40Z 2015-02-06T19:50:40Z 2013-07 2013-06 Article http://purl.org/eprint/type/JournalArticle 1523-7060 1523-7052 http://hdl.handle.net/1721.1/93912 Cheung, Chi Wai, and Stephen L. Buchwald. “Mild and General Palladium-Catalyzed Synthesis of Methyl Aryl Ethers Enabled by the Use of a Palladacycle Precatalyst.” Org. Lett. 15, no. 15 (August 2, 2013): 3998–4001. https://orcid.org/0000-0003-3875-4775 en_US http://dx.doi.org/10.1021/ol401796v Organic Letters Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Cheung, Chi Wai Buchwald, Stephen Leffler Mild and General Palladium-Catalyzed Synthesis of Methyl Aryl Ethers Enabled by the Use of a Palladacycle Precatalyst |
| title | Mild and General Palladium-Catalyzed Synthesis of Methyl Aryl Ethers Enabled by the Use of a Palladacycle Precatalyst |
| title_full | Mild and General Palladium-Catalyzed Synthesis of Methyl Aryl Ethers Enabled by the Use of a Palladacycle Precatalyst |
| title_fullStr | Mild and General Palladium-Catalyzed Synthesis of Methyl Aryl Ethers Enabled by the Use of a Palladacycle Precatalyst |
| title_full_unstemmed | Mild and General Palladium-Catalyzed Synthesis of Methyl Aryl Ethers Enabled by the Use of a Palladacycle Precatalyst |
| title_short | Mild and General Palladium-Catalyzed Synthesis of Methyl Aryl Ethers Enabled by the Use of a Palladacycle Precatalyst |
| title_sort | mild and general palladium catalyzed synthesis of methyl aryl ethers enabled by the use of a palladacycle precatalyst |
| url | http://hdl.handle.net/1721.1/93912 https://orcid.org/0000-0003-3875-4775 |
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