Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-tert-butylphosphino Biaryl Ligands
A series of palladacyclic precatalysts that incorporate electron-rich di-tert-butylphosphino biaryl ligands is reported. These precatalysts are easily prepared, and their use provides a general means of employing bulky ligands in palladium-catalyzed cross-coupling reactions. The application of these...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Chemical Society (ACS)
2015
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| Online Access: | http://hdl.handle.net/1721.1/93913 https://orcid.org/0000-0003-3875-4775 |
| _version_ | 1826200010993172480 |
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| author | Bruno, Nicholas C. Buchwald, Stephen Leffler |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Bruno, Nicholas C. Buchwald, Stephen Leffler |
| author_sort | Bruno, Nicholas C. |
| collection | MIT |
| description | A series of palladacyclic precatalysts that incorporate electron-rich di-tert-butylphosphino biaryl ligands is reported. These precatalysts are easily prepared, and their use provides a general means of employing bulky ligands in palladium-catalyzed cross-coupling reactions. The application of these palladium sources to various C–N and C–O bond-forming processes is also described. |
| first_indexed | 2024-09-23T11:29:50Z |
| format | Article |
| id | mit-1721.1/93913 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:29:50Z |
| publishDate | 2015 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/939132022-09-27T19:53:24Z Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-tert-butylphosphino Biaryl Ligands Bruno, Nicholas C. Buchwald, Stephen Leffler Massachusetts Institute of Technology. Department of Chemistry Bruno, Nicholas C. Buchwald, Stephen Leffler A series of palladacyclic precatalysts that incorporate electron-rich di-tert-butylphosphino biaryl ligands is reported. These precatalysts are easily prepared, and their use provides a general means of employing bulky ligands in palladium-catalyzed cross-coupling reactions. The application of these palladium sources to various C–N and C–O bond-forming processes is also described. National Institutes of Health (U.S.) (GM58160) National Institutes of Health (U.S.) (GM46059) Amgen Inc. 2015-02-06T19:56:45Z 2015-02-06T19:56:45Z 2013-05 2013-04 Article http://purl.org/eprint/type/JournalArticle 1523-7060 1523-7052 http://hdl.handle.net/1721.1/93913 Bruno, Nicholas C., and Stephen L. Buchwald. “Synthesis and Application of Palladium Precatalysts That Accommodate Extremely Bulky Di- Tert -Butylphosphino Biaryl Ligands.” Org. Lett. 15, no. 11 (June 7, 2013): 2876–2879. https://orcid.org/0000-0003-3875-4775 en_US http://dx.doi.org/10.1021/ol401208t Organic Letters Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Bruno, Nicholas C. Buchwald, Stephen Leffler Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-tert-butylphosphino Biaryl Ligands |
| title | Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-tert-butylphosphino Biaryl Ligands |
| title_full | Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-tert-butylphosphino Biaryl Ligands |
| title_fullStr | Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-tert-butylphosphino Biaryl Ligands |
| title_full_unstemmed | Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-tert-butylphosphino Biaryl Ligands |
| title_short | Synthesis and Application of Palladium Precatalysts that Accommodate Extremely Bulky Di-tert-butylphosphino Biaryl Ligands |
| title_sort | synthesis and application of palladium precatalysts that accommodate extremely bulky di tert butylphosphino biaryl ligands |
| url | http://hdl.handle.net/1721.1/93913 https://orcid.org/0000-0003-3875-4775 |
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