Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System
The trifluoromethylation of aryl/heteroaryl iodides has been demonstrated using a flow system, thus enabling a rapid rate of reaction. A broad spectrum of trifluoromethylated compounds was prepared in good to excellent yields using CF[subscript 3]CO[subscript 2]K as the trifluoromethyl source. The p...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Wiley Blackwell
2015
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| Online Access: | http://hdl.handle.net/1721.1/93915 https://orcid.org/0000-0003-3875-4775 https://orcid.org/0000-0002-7374-8680 |
| Summary: | The trifluoromethylation of aryl/heteroaryl iodides has been demonstrated using a flow system, thus enabling a rapid rate of reaction. A broad spectrum of trifluoromethylated compounds was prepared in good to excellent yields using CF[subscript 3]CO[subscript 2]K as the trifluoromethyl source. The process has the advantage of short reaction times and uses convenient [CF[subscript 3]] sources. |
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