Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System
The trifluoromethylation of aryl/heteroaryl iodides has been demonstrated using a flow system, thus enabling a rapid rate of reaction. A broad spectrum of trifluoromethylated compounds was prepared in good to excellent yields using CF[subscript 3]CO[subscript 2]K as the trifluoromethyl source. The p...
Main Authors: | Chen, Mao, Buchwald, Stephen Leffler |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Language: | en_US |
Published: |
Wiley Blackwell
2015
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Online Access: | http://hdl.handle.net/1721.1/93915 https://orcid.org/0000-0003-3875-4775 https://orcid.org/0000-0002-7374-8680 |
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