Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts
A wide range of biaryls were synthesized by palladium-catalyzed Negishi cross-couplings at ambient temperature or with low catalyst loading. This protocol features the use of a recently reported aminobiphenyl palladacycle precatalyst to generate the catalytically active XPhosPd[superscript 0] specie...
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| Format: | Article |
| Language: | en_US |
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Wiley Blackwell
2015
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| Online Access: | http://hdl.handle.net/1721.1/93921 https://orcid.org/0000-0003-3875-4775 |
| _version_ | 1826209968876945408 |
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| author | Yang, Yang Oldenhuis, Nathan J. Buchwald, Stephen Leffler |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Yang, Yang Oldenhuis, Nathan J. Buchwald, Stephen Leffler |
| author_sort | Yang, Yang |
| collection | MIT |
| description | A wide range of biaryls were synthesized by palladium-catalyzed Negishi cross-couplings at ambient temperature or with low catalyst loading. This protocol features the use of a recently reported aminobiphenyl palladacycle precatalyst to generate the catalytically active XPhosPd[superscript 0] species. Significantly, a wide range of challenging heterocyclic and polyfluorinated aromatic substrates can be employed to give products in excellent yields. |
| first_indexed | 2024-09-23T14:37:44Z |
| format | Article |
| id | mit-1721.1/93921 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:37:44Z |
| publishDate | 2015 |
| publisher | Wiley Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/939212022-10-01T21:51:07Z Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts Yang, Yang Oldenhuis, Nathan J. Buchwald, Stephen Leffler Massachusetts Institute of Technology. Department of Chemistry Yang, Yang Oldenhuis, Nathan J. Buchwald, Stephen Leffler A wide range of biaryls were synthesized by palladium-catalyzed Negishi cross-couplings at ambient temperature or with low catalyst loading. This protocol features the use of a recently reported aminobiphenyl palladacycle precatalyst to generate the catalytically active XPhosPd[superscript 0] species. Significantly, a wide range of challenging heterocyclic and polyfluorinated aromatic substrates can be employed to give products in excellent yields. National Institutes of Health (U.S.) (GM46059) 2015-02-06T20:35:11Z 2015-02-06T20:35:11Z 2012-11 2012-09 Article http://purl.org/eprint/type/JournalArticle 14337851 1521-3773 http://hdl.handle.net/1721.1/93921 Yang, Yang, Nathan J. Oldenhuis, and Stephen L. Buchwald. “Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts.” Angewandte Chemie International Edition 52, no. 2 (November 22, 2012): 615–619. https://orcid.org/0000-0003-3875-4775 en_US http://dx.doi.org/10.1002/anie.201207750 Angewandte Chemie International Edition Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley Blackwell PMC |
| spellingShingle | Yang, Yang Oldenhuis, Nathan J. Buchwald, Stephen Leffler Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts |
| title | Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts |
| title_full | Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts |
| title_fullStr | Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts |
| title_full_unstemmed | Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts |
| title_short | Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts |
| title_sort | mild and general conditions for negishi cross coupling enabled by the use of palladacycle precatalysts |
| url | http://hdl.handle.net/1721.1/93921 https://orcid.org/0000-0003-3875-4775 |
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