Evaluation of the Potential Impact of Ebola Virus Genomic Drift on the Efficacy of Sequence-Based Candidate Therapeutics

Evaluation of the Potential Impact of Ebola Virus Genomic Drift on the Efficacy of Sequence-Based Candidate Therapeutics

Until recently, Ebola virus (EBOV) was a rarely encountered human pathogen that caused disease among small populations with extraordinarily high lethality. At the end of 2013, EBOV initiated an unprecedented disease outbreak in West Africa that is still ongoing and has already caused thousands of de...

Full description

Bibliographic Details
Main Authors:	Kugelman, Jeffrey R., Sanchez-Lockhart, Mariano, Andersen, Kristian G., Gire, Stephen, Park, Daniel J., Lin, Aaron E., Wohl, Shirlee, Sabeti, Pardis C., Kuhn, Jens H., Palacios, Gustavo F., Sealfon, Rachel Sima
Other Authors:	Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format:	Article
Language:	en_US
Published:	American Society for Microbiology 2015
Online Access:	http://hdl.handle.net/1721.1/94325

Similar Items

Evaluation of the Potential Impact of Ebola Virus Genomic Drift on the Efficacy of Sequence-Based Candidate Therapeutics
by: Jeffrey R. Kugelman, et al.
Published: (2015-02-01)

Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
by: Sealfon, Rachel Sima, et al.
Published: (2015)

Monitoring of Ebola Virus Makona Evolution through Establishment of Advanced Genomic Capability in Liberia
by: Jeffrey R. Kugelman, et al.
Published: (2015-07-01)

Emergence of Ebola Virus Escape Variants in Infected Nonhuman Primates Treated with the MB-003 Antibody Cocktail
by: Jeffrey R. Kugelman, et al.
Published: (2015-09-01)

Single-cell profiling of lncRNA expression during Ebola virus infection in rhesus macaques
by: Luisa Santus, et al.
Published: (2023-06-01)

Nomenclature- and database-compatible names for the two Ebola virus variants that emerged in Guinea and the Democratic Republic of the Congo in 2014
by: Sealfon, Rachel
Published: (2020)

On-Demand Patient-Specific Phenotype-to-Genotype Ebola Virus Characterization
by: Brett F. Beitzel, et al.
Published: (2021-10-01)

ISCB Ebola Award for Important Future Research on the Computational Biology of Ebola Virus
by: Karp, Peter D., et al.
Published: (2015)

ISCB Ebola Award for Important Future Research on the Computational Biology of Ebola Virus.
by: Peter D. Karp, et al.
Published: (2015-01-01)

Informing the Historical Record of Experimental Nonhuman Primate Infections with Ebola Virus: Genomic Characterization of USAMRIID Ebola Virus/H.sapiens-tc/COD/1995/Kikwit-9510621 Challenge Stock "R4368" and Its Replacement "R4415".
by: Jeffrey R Kugelman, et al.
Published: (2016-01-01)

Nomenclature- and Database-Compatible Names for the Two Ebola Virus Variants that Emerged in Guinea and the Democratic Republic of the Congo in 2014
by: Jens H. Kuhn, et al.
Published: (2014-11-01)

Error baseline rates of five sample preparation methods used to characterize RNA virus populations.
by: Jeffrey R Kugelman, et al.
Published: (2017-01-01)

Reporter Assays for Ebola Virus Nucleoprotein Oligomerization, Virion-Like Particle Budding, and Minigenome Activity Reveal the Importance of Nucleoprotein Amino Acid Position 111
by: Aaron E. Lin, et al.
Published: (2020-01-01)

High depth, whole-genome sequencing of cholera isolates from Haiti and the Dominican Republic
by: Gire, Stephen, et al.
Published: (2012)

Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus
by: Sealfon, Rachel Sima
Published: (2017)

Transforming Clinical Data into Actionable Prognosis Models: Machine-Learning Framework and Field-Deployable App to Predict Outcome of Ebola Patients.
by: Andres Colubri, et al.
Published: (2016-03-01)

Ebola vaccines in clinical trial: The promising candidates
by: Yuxiao Wang, et al.
Published: (2017-01-01)

Predicting enhancer regions and transcription factor binding sites in D. melanogaster
by: Sealfon, Rachel (Rachel Sima)
Published: (2011)

Computational investigation of pathogen evolution
by: Sealfon, Rachel (Rachel Sima)
Published: (2015)

FRESCo: finding regions of excess synonymous constraint in diverse viruses
by: Lin, Michael F., et al.
Published: (2015)

Ebola virus genome plasticity as a marker of its passaging history: a comparison of in vitro passaging to non-human primate infection.
by: Jeffrey R Kugelman, et al.
Published: (2012-01-01)

Evaluation of Signature Erosion in Ebola Virus Due to Genomic Drift and Its Impact on the Performance of Diagnostic Assays
by: Shanmuga Sozhamannan, et al.
Published: (2015-06-01)

An immunotoxin targeting Ebola virus glycoprotein inhibits Ebola virus production from infected cells.
by: Yingyun Cai, et al.
Published: (2021-01-01)

Sample size calculation for phylogenetic case linkage.
by: Shirlee Wohl, et al.
Published: (2021-07-01)

Phylodynamic Analysis of Ebola Virus Disease Transmission in Sierra Leone
by: Petrus Jansen van Vuren, et al.
Published: (2019-01-01)

A Novel Ebola Virus VP40 Matrix Protein-Based Screening for Identification of Novel Candidate Medical Countermeasures
by: Ryan P. Bennett, et al.
Published: (2020-12-01)

Designs and Characterization of Subunit Ebola GP Vaccine Candidates: Implications for Immunogenicity
by: Valentina Agnolon, et al.
Published: (2020-11-01)

Drifting absence :: drafting memory
by: Kuhn, Marlene Eva
Published: (2007)

The impact of semen testing for Ebola virus RNA on sexual behavior of male Ebola survivors in Liberia.
by: Kathleen Tompkins, et al.
Published: (2020-09-01)

Machine-learning Prognostic Models from the 2014–16 Ebola Outbreak: Data-harmonization Challenges, Validation Strategies, and mHealth Applications
by: Andres Colubri, et al.
Published: (2019-05-01)

YF17D-vectored Ebola vaccine candidate protects mice against lethal surrogate Ebola and yellow fever virus challenge
by: Viktor Lemmens, et al.
Published: (2023-07-01)

Vaccines against Ebola virus and Marburg virus: recent advances and promising candidates
by: John J. Suschak, et al.
Published: (2019-10-01)

Commentary to "Ethicizing the Ebola Epidemic"
by: Rachel Hill
Published: (2014-10-01)

Epitope mapping of Ebola virus dominant and subdominant glycoprotein epitopes facilitates construction of an epitope-based DNA vaccine able to focus the antibody response in mice
by: Daniel A. J. Mitchell, et al.
Published: (2017-12-01)

Nonhuman primate to human immunobridging to infer the protective effect of an Ebola virus vaccine candidate
by: Ramon Roozendaal, et al.
Published: (2020-12-01)

Histology, immunohistochemistry, and in situ hybridization reveal overlooked Ebola virus target tissues in the Ebola virus disease guinea pig model
by: Timothy K. Cooper, et al.
Published: (2018-01-01)

EBOLA
by: Tadeja Kotar
Published: (2014-12-01)

The prevalence of Post-Ebola Syndrome hearing loss, Sierra Leone
by: Samuel C. Ficenec, et al.
Published: (2022-07-01)

Chainchecker: An application to visualise and explore transmission chains for Ebola virus disease.
by: Katy Gaythorpe, et al.
Published: (2021-01-01)

Drift Velocity with Elastic Scattering
by: Rachel M. Morin, et al.
Published: (2023-11-01)