Yeast Reveal a ‘Druggable’ Rsp5/Nedd4 Network That Ameliorates α-Synuclein Toxicity in Neurons

Yeast Reveal a ‘Druggable’ Rsp5/Nedd4 Network That Ameliorates α-Synuclein Toxicity in Neurons

α-Synuclein (α-syn) is a small lipid-binding protein implicated in several neurodegenerative diseases, including Parkinson’s disease, whose pathobiology is conserved from yeast to man. There are no therapies targeting these underlying cellular pathologies, or indeed those of any major neurodegenerat...

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Bibliographic Details
Main Authors:	Jui, Nathan T., Buchwald, Stephen Leffler, Lindquist, Susan, Tardiff, Daniel F., Khurana, Vikram, Tambe, Mitali A., Thompson, Michelle L., Chung, Chee Yeun, Kamadurai, Hari B., Kim, Hyoung Tae, Lancaster, Alex K., Caldwell, Kim A., Caldwell, Guy A., Rochet, Jean-Christophe
Other Authors:	Massachusetts Institute of Technology. Department of Biology
Format:	Article
Language:	en_US
Published:	American Association for the Advancement of Science (AAAS) 2015
Online Access:	http://hdl.handle.net/1721.1/94504 https://orcid.org/0000-0003-1307-882X https://orcid.org/0000-0003-3875-4775

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