Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand
A platinum(II) complex of a monoanionic, tetradentate β-diketiminate (BDI) ligand with pendant quinoline arms, BDIQQH, is reported. The complex, [Pt(BDI[superscript QQ])]Cl, is emissive in DMSO, but non-emissive in aqueous buffer. Upon binding DNA in buffer, however, a 150-fold turn-on in emission i...
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| Format: | Article |
| Language: | en_US |
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Royal Society of Chemistry, The
2015
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| Online Access: | http://hdl.handle.net/1721.1/95424 https://orcid.org/0000-0002-2693-4982 |
| _version_ | 1811093182310514688 |
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| author | Hope, Jennifer M. Wilson, Justin J. Lippard, Stephen J. |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Hope, Jennifer M. Wilson, Justin J. Lippard, Stephen J. |
| author_sort | Hope, Jennifer M. |
| collection | MIT |
| description | A platinum(II) complex of a monoanionic, tetradentate β-diketiminate (BDI) ligand with pendant quinoline arms, BDIQQH, is reported. The complex, [Pt(BDI[superscript QQ])]Cl, is emissive in DMSO, but non-emissive in aqueous buffer. Upon binding DNA in buffer, however, a 150-fold turn-on in emission intensity occurs. Dynamic light scattering and [superscript 1]H NMR spectroscopy indicate that [Pt(BDI[superscript QQ])]Cl forms non-emissive aggregates in aqueous solution; DNA-binding disperses the aggregates leading to the large emission turn-on response. The cytotoxic activity of the complex, measured in two cancer cell lines, is comparable to or better than that of the established anticancer drug cisplatin. |
| first_indexed | 2024-09-23T15:40:58Z |
| format | Article |
| id | mit-1721.1/95424 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:40:58Z |
| publishDate | 2015 |
| publisher | Royal Society of Chemistry, The |
| record_format | dspace |
| spelling | mit-1721.1/954242022-09-29T15:28:20Z Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand Hope, Jennifer M. Wilson, Justin J. Lippard, Stephen J. Massachusetts Institute of Technology. Department of Chemistry Lippard, Stephen J. Hope, Jennifer M. Wilson, Justin J. A platinum(II) complex of a monoanionic, tetradentate β-diketiminate (BDI) ligand with pendant quinoline arms, BDIQQH, is reported. The complex, [Pt(BDI[superscript QQ])]Cl, is emissive in DMSO, but non-emissive in aqueous buffer. Upon binding DNA in buffer, however, a 150-fold turn-on in emission intensity occurs. Dynamic light scattering and [superscript 1]H NMR spectroscopy indicate that [Pt(BDI[superscript QQ])]Cl forms non-emissive aggregates in aqueous solution; DNA-binding disperses the aggregates leading to the large emission turn-on response. The cytotoxic activity of the complex, measured in two cancer cell lines, is comparable to or better than that of the established anticancer drug cisplatin. National Cancer Institute (U.S.) (Grant CA034992) David H. Koch Graduate Fellowship National Institutes of Health (U.S.) (Grant 1S10RR13886) 2015-02-19T20:48:20Z 2015-02-19T20:48:20Z 2012-11 2012-10 Article http://purl.org/eprint/type/JournalArticle 1477-9226 1477-9234 http://hdl.handle.net/1721.1/95424 Hope, Jennifer M., Justin J. Wilson, and Stephen J. Lippard. “Photoluminescent DNA Binding and Cytotoxic Activity of a Platinum(ii) Complex Bearing a Tetradentate β-Diketiminate Ligand.” Dalton Transactions 42, no. 9 (2013): 3176. https://orcid.org/0000-0002-2693-4982 en_US http://dx.doi.org/10.1039/c2dt32462h Dalton Transactions Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Royal Society of Chemistry, The PMC |
| spellingShingle | Hope, Jennifer M. Wilson, Justin J. Lippard, Stephen J. Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand |
| title | Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand |
| title_full | Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand |
| title_fullStr | Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand |
| title_full_unstemmed | Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand |
| title_short | Photoluminescent DNA binding and cytotoxic activity of a platinum(ii) complex bearing a tetradentate β-diketiminate ligand |
| title_sort | photoluminescent dna binding and cytotoxic activity of a platinum ii complex bearing a tetradentate β diketiminate ligand |
| url | http://hdl.handle.net/1721.1/95424 https://orcid.org/0000-0002-2693-4982 |
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