Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice
Women are more resistant to hepatocellular carcinoma (HCC) than men despite equal exposure to major risk factors, such as hepatitis B or C virus infection. Female resistance is hormone-dependent, as evidenced by the sharp increase in HCC incidence in postmenopausal women who do not take hormone repl...
Main Authors: | Hartwell, Hadley J., Petrosky, Keiko Y., Fox, James G., Horseman, Nelson D., Rogers, Arlin B. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | en_US |
Published: |
National Academy of Sciences (U.S.)
2015
|
Online Access: | http://hdl.handle.net/1721.1/95792 https://orcid.org/0000-0001-9307-6116 |
Similar Items
-
Identification and validation of functional roles for three MYC-associated genes in hepatocellular carcinoma
by: Sha Li, et al.
Published: (2023-12-01) -
MYC and MET cooperatively drive hepatocellular carcinoma with distinct molecular traits and vulnerabilities
by: Celia Sequera, et al.
Published: (2022-11-01) -
Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma
by: Anja Deutzmann, et al.
Published: (2024-02-01) -
Insulin Resistance and Metabolic Hepatocarcinogenesis with Parent-of-Origin Effects in A×B Mice
by: Hines, Ian N., et al.
Published: (2016) -
PHAROH lncRNA regulates Myc translation in hepatocellular carcinoma via sequestering TIAR
by: Allen T Yu, et al.
Published: (2021-05-01)