Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

Caspase-2-Mediated Cleavage of Mdm2 Creates a p53-Induced Positive Feedback Loop

Caspase-2 is an evolutionarily conserved caspase, yet its biological function and cleavage targets are poorly understood. Caspase-2 is activated by the p53 target gene product PIDD (also known as LRDD) in a complex called the Caspase-2-PIDDosome. We show that PIDD expression promotes growth arrest a...

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Bibliographic Details
Main Authors: Oliver, Trudy, Meylan, Etienne, Chang, Gregory P., Xue, Wen, Burke, James R., Humpton, Timothy J., Hubbard, Diana D., Bhutkar, Arjun (AJ), Jacks, Tyler E.
Other Authors: Koch Institute for Integrative Cancer Research at MIT
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/95804
https://orcid.org/0000-0001-5785-8911

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