Causal evidence for the behavioral impact of oscillations in neocortex and hippocampus
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 2014.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2015
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| Online Access: | http://hdl.handle.net/1721.1/95857 |
| _version_ | 1811088393712435200 |
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| author | Siegle, Joshua H. (Joshua Hangman) |
| author2 | Matthew A. Wilson. |
| author_facet | Matthew A. Wilson. Siegle, Joshua H. (Joshua Hangman) |
| author_sort | Siegle, Joshua H. (Joshua Hangman) |
| collection | MIT |
| description | Thesis: Ph. D., Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 2014. |
| first_indexed | 2024-09-23T14:01:29Z |
| format | Thesis |
| id | mit-1721.1/95857 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T14:01:29Z |
| publishDate | 2015 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/958572019-06-06T03:14:10Z Causal evidence for the behavioral impact of oscillations in neocortex and hippocampus Siegle, Joshua H. (Joshua Hangman) Matthew A. Wilson. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences. Brain and Cognitive Sciences. Thesis: Ph. D., Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 2014. Cataloged from PDF version of thesis. Includes bibliographical references. Neuroscientists hold widely divergent opinions on the behavioral relevance of oscillatory brain states. Some consider them to be a side effect of anatomical connectivity, with little or no role in guiding action. Others view them as a fundamental feature of the network states that underlie perception and cognition. In this thesis, I take a systematic approach to studying two of the most prominent types of oscillations,'gamma rhythms in the neocortex (30-80 Hz) and theta rhythms in the hippocampus (4-12 Hz). In both cases, I use light-gated ion channels to manipulate spike activity on a cycle-by-cycle basis in awake, behaving mice. By rhythmically stimulating fast-spiking interneurons in somatosensory cortex, I can emulate the activity patterns that define gamma oscillations under natural conditions. Emulating gamma enhances the detection of threshold-level vibrissae deflections, analogous to the behavioral effects of shifting attention. By triggering stimulation of fast-spiking interneurons in the hippocampus on peaks and troughs of endogenous rhythms, I can reduce spike activity at specific phases of theta. In the context of a spatial navigation task, I find that the ability of inhibition to enhance decision-making accuracy depends on both the theta phase and the task segment in which it occurs. Both of these experiments provide novel causal evidence for the behavioral impact of oscillations, which offers a much more compelling argument for their utility than traditional correlative measures. Finally, I present a new platform for extracellular electrophysiology. This platform, called Open Ephys, makes the closed-loop experiments that are ideal for studying oscillations accessible to a wider audience. by Joshua H. Siegle. Ph. D. 2015-03-05T15:56:56Z 2015-03-05T15:56:56Z 2014 2014 Thesis http://hdl.handle.net/1721.1/95857 903930274 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 170 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Brain and Cognitive Sciences. Siegle, Joshua H. (Joshua Hangman) Causal evidence for the behavioral impact of oscillations in neocortex and hippocampus |
| title | Causal evidence for the behavioral impact of oscillations in neocortex and hippocampus |
| title_full | Causal evidence for the behavioral impact of oscillations in neocortex and hippocampus |
| title_fullStr | Causal evidence for the behavioral impact of oscillations in neocortex and hippocampus |
| title_full_unstemmed | Causal evidence for the behavioral impact of oscillations in neocortex and hippocampus |
| title_short | Causal evidence for the behavioral impact of oscillations in neocortex and hippocampus |
| title_sort | causal evidence for the behavioral impact of oscillations in neocortex and hippocampus |
| topic | Brain and Cognitive Sciences. |
| url | http://hdl.handle.net/1721.1/95857 |
| work_keys_str_mv | AT sieglejoshuahjoshuahangman causalevidenceforthebehavioralimpactofoscillationsinneocortexandhippocampus |