Cellular Decision Making and Biological Noise: From Microbes to Mammals
Cellular decision making is the process whereby cells assume different, functionally important and heritable fates without an associated genetic or environmental difference. Such stochastic cell fate decisions generate nongenetic cellular diversity, which may be critical for metazoan development as...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/95879 |
| _version_ | 1826212946015944704 |
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| author | Balazsi, Gabor van Oudenaarden, Alexander Collins, James J. van Oudenaarden, Alexander |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Balazsi, Gabor van Oudenaarden, Alexander Collins, James J. van Oudenaarden, Alexander |
| author_sort | Balazsi, Gabor |
| collection | MIT |
| description | Cellular decision making is the process whereby cells assume different, functionally important and heritable fates without an associated genetic or environmental difference. Such stochastic cell fate decisions generate nongenetic cellular diversity, which may be critical for metazoan development as well as optimized microbial resource utilization and survival in a fluctuating, frequently stressful environment. Here, we review several examples of cellular decision making from viruses, bacteria, yeast, lower metazoans, and mammals, highlighting the role of regulatory network structure and molecular noise. We propose that cellular decision making is one of at least three key processes underlying development at various scales of biological organization. |
| first_indexed | 2024-09-23T15:40:58Z |
| format | Article |
| id | mit-1721.1/95879 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:40:58Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/958792022-09-29T15:25:57Z Cellular Decision Making and Biological Noise: From Microbes to Mammals Balazsi, Gabor van Oudenaarden, Alexander Collins, James J. van Oudenaarden, Alexander Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Physics van Oudenaarden, Alexander Collins, James J. Cellular decision making is the process whereby cells assume different, functionally important and heritable fates without an associated genetic or environmental difference. Such stochastic cell fate decisions generate nongenetic cellular diversity, which may be critical for metazoan development as well as optimized microbial resource utilization and survival in a fluctuating, frequently stressful environment. Here, we review several examples of cellular decision making from viruses, bacteria, yeast, lower metazoans, and mammals, highlighting the role of regulatory network structure and molecular noise. We propose that cellular decision making is one of at least three key processes underlying development at various scales of biological organization. National Cancer Institute (U.S.). Physical Sciences-Oncology Center (U54CA143874) National Institutes of Health (U.S.). Pioneer Award (1DP1OD003936) National Institutes of Health (U.S.). Pioneer Award (DP1 OD00344) Howard Hughes Medical Institute Ellison Medical Foundation National Institutes of Health (U.S.) (Grant RC2 HL102815) National Institutes of Health (U.S.) (Grant RL1 DE019021) 2015-03-05T17:10:56Z 2015-03-05T17:10:56Z 2011-03 Article http://purl.org/eprint/type/JournalArticle 00928674 1097-4172 http://hdl.handle.net/1721.1/95879 Balazsi, Gabor, Alexander van Oudenaarden, and James J. Collins. “Cellular Decision Making and Biological Noise: From Microbes to Mammals.” Cell 144, no. 6 (March 2011): 910–925. © 2011 Elsevier Inc. en_US http://dx.doi.org/10.1016/j.cell.2011.01.030 Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier |
| spellingShingle | Balazsi, Gabor van Oudenaarden, Alexander Collins, James J. van Oudenaarden, Alexander Cellular Decision Making and Biological Noise: From Microbes to Mammals |
| title | Cellular Decision Making and Biological Noise: From Microbes to Mammals |
| title_full | Cellular Decision Making and Biological Noise: From Microbes to Mammals |
| title_fullStr | Cellular Decision Making and Biological Noise: From Microbes to Mammals |
| title_full_unstemmed | Cellular Decision Making and Biological Noise: From Microbes to Mammals |
| title_short | Cellular Decision Making and Biological Noise: From Microbes to Mammals |
| title_sort | cellular decision making and biological noise from microbes to mammals |
| url | http://hdl.handle.net/1721.1/95879 |
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