ATP Consumption Promotes Cancer Metabolism
Cancer cells metabolize glucose by aerobic glycolysis, a phenomenon known as the Warburg effect. Fang et al. (2010) show that the endoplasmic reticulum enzyme ENTPD5 promotes ATP consumption and favors aerobic glycolysis. The findings suggest that nutrient uptake in cancer cells is limited by ATP an...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/96047 https://orcid.org/0000-0002-6702-4192 |
| _version_ | 1826204789861515264 |
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| author | Israelsen, William James Vander Heiden, Matthew G. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Israelsen, William James Vander Heiden, Matthew G. |
| author_sort | Israelsen, William James |
| collection | MIT |
| description | Cancer cells metabolize glucose by aerobic glycolysis, a phenomenon known as the Warburg effect. Fang et al. (2010) show that the endoplasmic reticulum enzyme ENTPD5 promotes ATP consumption and favors aerobic glycolysis. The findings suggest that nutrient uptake in cancer cells is limited by ATP and satisfies energy requirements other than ATP production. |
| first_indexed | 2024-09-23T13:01:26Z |
| format | Article |
| id | mit-1721.1/96047 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:01:26Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/960472022-09-28T11:30:42Z ATP Consumption Promotes Cancer Metabolism Israelsen, William James Vander Heiden, Matthew G. Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Vander Heiden, Matthew G. Israelsen, William James Cancer cells metabolize glucose by aerobic glycolysis, a phenomenon known as the Warburg effect. Fang et al. (2010) show that the endoplasmic reticulum enzyme ENTPD5 promotes ATP consumption and favors aerobic glycolysis. The findings suggest that nutrient uptake in cancer cells is limited by ATP and satisfies energy requirements other than ATP production. 2015-03-17T17:22:39Z 2015-03-17T17:22:39Z 2010-11 Article http://purl.org/eprint/type/JournalArticle 00928674 1097-4172 http://hdl.handle.net/1721.1/96047 Israelsen, William J., and Matthew G. Vander Heiden. “ATP Consumption Promotes Cancer Metabolism.” Cell 143, no. 5 (November 2010): 669–671. © 2010 Elsevier Inc. https://orcid.org/0000-0002-6702-4192 en_US http://dx.doi.org/10.1016/j.cell.2010.11.010 Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier |
| spellingShingle | Israelsen, William James Vander Heiden, Matthew G. ATP Consumption Promotes Cancer Metabolism |
| title | ATP Consumption Promotes Cancer Metabolism |
| title_full | ATP Consumption Promotes Cancer Metabolism |
| title_fullStr | ATP Consumption Promotes Cancer Metabolism |
| title_full_unstemmed | ATP Consumption Promotes Cancer Metabolism |
| title_short | ATP Consumption Promotes Cancer Metabolism |
| title_sort | atp consumption promotes cancer metabolism |
| url | http://hdl.handle.net/1721.1/96047 https://orcid.org/0000-0002-6702-4192 |
| work_keys_str_mv | AT israelsenwilliamjames atpconsumptionpromotescancermetabolism AT vanderheidenmatthewg atpconsumptionpromotescancermetabolism |