Differential Dynamics of Activity Changes in Dorsolateral and Dorsomedial Striatal Loops during Learning
The basal ganglia are implicated in a remarkable range of functions influencing emotion and cognition as well as motor behavior. Current models of basal ganglia function hypothesize that parallel limbic, associative, and motor cortico-basal ganglia loops contribute to this diverse set of functions,...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/96048 https://orcid.org/0000-0002-4326-7720 |
| _version_ | 1811072232270594048 |
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| author | Thorn, Catherine A. Atallah, Hicham Howe, Mark William Graybiel, Ann M. |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Thorn, Catherine A. Atallah, Hicham Howe, Mark William Graybiel, Ann M. |
| author_sort | Thorn, Catherine A. |
| collection | MIT |
| description | The basal ganglia are implicated in a remarkable range of functions influencing emotion and cognition as well as motor behavior. Current models of basal ganglia function hypothesize that parallel limbic, associative, and motor cortico-basal ganglia loops contribute to this diverse set of functions, but little is yet known about how these loops operate and how their activities evolve during learning. To address these issues, we recorded simultaneously in sensorimotor and associative regions of the striatum as rats learned different versions of a conditional T-maze task. We found highly contrasting patterns of activity in these regions during task performance and found that these different patterns of structured activity developed concurrently, but with sharply different dynamics. Based on the region-specific dynamics of these patterns across learning, we suggest a working model whereby dorsomedial associative loops can modulate the access of dorsolateral sensorimotor loops to the control of action. |
| first_indexed | 2024-09-23T09:02:43Z |
| format | Article |
| id | mit-1721.1/96048 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:02:43Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/960482022-09-30T13:01:40Z Differential Dynamics of Activity Changes in Dorsolateral and Dorsomedial Striatal Loops during Learning Thorn, Catherine A. Atallah, Hicham Howe, Mark William Graybiel, Ann M. Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science McGovern Institute for Brain Research at MIT Graybiel, Ann M. Thorn, Catherine A. Atallah, Hicham Howe, Mark William The basal ganglia are implicated in a remarkable range of functions influencing emotion and cognition as well as motor behavior. Current models of basal ganglia function hypothesize that parallel limbic, associative, and motor cortico-basal ganglia loops contribute to this diverse set of functions, but little is yet known about how these loops operate and how their activities evolve during learning. To address these issues, we recorded simultaneously in sensorimotor and associative regions of the striatum as rats learned different versions of a conditional T-maze task. We found highly contrasting patterns of activity in these regions during task performance and found that these different patterns of structured activity developed concurrently, but with sharply different dynamics. Based on the region-specific dynamics of these patterns across learning, we suggest a working model whereby dorsomedial associative loops can modulate the access of dorsolateral sensorimotor loops to the control of action. National Institutes of Health (U.S.) (MH60379) United States. Office of Naval Research (N000140410208) Stanley H. and Sheila G. Sydney Fund European Union (Grant 201716) McGovern Institute for Brain Research at MIT (Fellowship) 2015-03-17T17:30:12Z 2015-03-17T17:30:12Z 2010-06 2010-04 Article http://purl.org/eprint/type/JournalArticle 08966273 1097-4199 http://hdl.handle.net/1721.1/96048 Thorn, Catherine A., Hisham Atallah, Mark Howe, and Ann M. Graybiel. “Differential Dynamics of Activity Changes in Dorsolateral and Dorsomedial Striatal Loops During Learning.” Neuron 66, no. 5 (June 2010): 781–795. © 2010 Elsevier Inc. https://orcid.org/0000-0002-4326-7720 en_US http://dx.doi.org/10.1016/j.neuron.2010.04.036 Neuron Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier |
| spellingShingle | Thorn, Catherine A. Atallah, Hicham Howe, Mark William Graybiel, Ann M. Differential Dynamics of Activity Changes in Dorsolateral and Dorsomedial Striatal Loops during Learning |
| title | Differential Dynamics of Activity Changes in Dorsolateral and Dorsomedial Striatal Loops during Learning |
| title_full | Differential Dynamics of Activity Changes in Dorsolateral and Dorsomedial Striatal Loops during Learning |
| title_fullStr | Differential Dynamics of Activity Changes in Dorsolateral and Dorsomedial Striatal Loops during Learning |
| title_full_unstemmed | Differential Dynamics of Activity Changes in Dorsolateral and Dorsomedial Striatal Loops during Learning |
| title_short | Differential Dynamics of Activity Changes in Dorsolateral and Dorsomedial Striatal Loops during Learning |
| title_sort | differential dynamics of activity changes in dorsolateral and dorsomedial striatal loops during learning |
| url | http://hdl.handle.net/1721.1/96048 https://orcid.org/0000-0002-4326-7720 |
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