Frameshift Mutagenesis and Microsatellite Instability Induced by Human Alkyladenine DNA Glycosylase

Frameshift Mutagenesis and Microsatellite Instability Induced by Human Alkyladenine DNA Glycosylase

Human alkyladenine DNA glycosylase (hAAG) excises alkylated purines, hypoxanthine, and etheno bases from DNA to form abasic (AP) sites. Surprisingly, elevated expression of hAAG increases spontaneous frameshift mutagenesis. By random mutagenesis of eight active site residues, we isolated hAAG-Y127I/...

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Bibliographic Details
Main Authors:	Klapacz, Joanna, Lingaraju, Gondichatnahalli M., Guo, Haiwei H., Shah, Dharini, Moar-Shoshani, Ayelet, Loeb, Lawrence A., Samson, Leona D.
Other Authors:	Massachusetts Institute of Technology. Center for Environmental Health Sciences
Format:	Article
Language:	en_US
Published:	Elsevier 2015
Online Access:	http://hdl.handle.net/1721.1/96053 https://orcid.org/0000-0002-7112-1454

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