Response Features of Parvalbumin-Expressing Interneurons Suggest Precise Roles for Subtypes of Inhibition in Visual Cortex
Inhibitory interneurons in the cerebral cortex include a vast array of subtypes, varying in their molecular signatures, electrophysiological properties, and connectivity patterns. This diversity suggests that individual inhibitory classes have unique roles in cortical circuits; however, their charac...
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| Format: | Article |
| Language: | en_US |
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Elsevier
2015
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| Online Access: | http://hdl.handle.net/1721.1/96068 https://orcid.org/0000-0002-6719-7085 https://orcid.org/0000-0003-2442-5671 |
| _version_ | 1811088743278313472 |
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| author | Runyan, Caroline A. Schummers, James Van Wart, Audra Kuhlman, Sandra J. Wilson, Nathan R. Huang, Z. Josh Sur, Mriganka |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Runyan, Caroline A. Schummers, James Van Wart, Audra Kuhlman, Sandra J. Wilson, Nathan R. Huang, Z. Josh Sur, Mriganka |
| author_sort | Runyan, Caroline A. |
| collection | MIT |
| description | Inhibitory interneurons in the cerebral cortex include a vast array of subtypes, varying in their molecular signatures, electrophysiological properties, and connectivity patterns. This diversity suggests that individual inhibitory classes have unique roles in cortical circuits; however, their characterization to date has been limited to broad classifications including many subtypes. We used the Cre/LoxP system, specifically labeling parvalbumin(PV)-expressing interneurons in visual cortex of PV-Cre mice with red fluorescent protein (RFP), followed by targeted loose-patch recordings and two-photon imaging of calcium responses in vivo to characterize the visual receptive field properties of these cells. Despite their relative molecular and morphological homogeneity, we find that PV[superscript +] neurons have a diversity of feature-specific visual responses that include sharp orientation and direction-selectivity, small receptive fields, and band-pass spatial frequency tuning. These results suggest that subsets of parvalbumin interneurons are components of specific cortical networks and that perisomatic inhibition contributes to the generation of precise response properties. |
| first_indexed | 2024-09-23T14:06:50Z |
| format | Article |
| id | mit-1721.1/96068 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:06:50Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/960682022-10-01T19:16:16Z Response Features of Parvalbumin-Expressing Interneurons Suggest Precise Roles for Subtypes of Inhibition in Visual Cortex Runyan, Caroline A. Schummers, James Van Wart, Audra Kuhlman, Sandra J. Wilson, Nathan R. Huang, Z. Josh Sur, Mriganka Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory Sur, Mriganka Runyan, Caroline A. Schummers, James Van Wart, Audra Wilson, Nathan R. Inhibitory interneurons in the cerebral cortex include a vast array of subtypes, varying in their molecular signatures, electrophysiological properties, and connectivity patterns. This diversity suggests that individual inhibitory classes have unique roles in cortical circuits; however, their characterization to date has been limited to broad classifications including many subtypes. We used the Cre/LoxP system, specifically labeling parvalbumin(PV)-expressing interneurons in visual cortex of PV-Cre mice with red fluorescent protein (RFP), followed by targeted loose-patch recordings and two-photon imaging of calcium responses in vivo to characterize the visual receptive field properties of these cells. Despite their relative molecular and morphological homogeneity, we find that PV[superscript +] neurons have a diversity of feature-specific visual responses that include sharp orientation and direction-selectivity, small receptive fields, and band-pass spatial frequency tuning. These results suggest that subsets of parvalbumin interneurons are components of specific cortical networks and that perisomatic inhibition contributes to the generation of precise response properties. National Institutes of Health (U.S.) (Fellowship F31N067951) National Institutes of Health (U.S.) (Training Grant T32 MH074249) National Institutes of Health (U.S.) (Training Grant T32EY013935) National Institutes of Health (U.S.) (Fellowship F32EY018065) National Institutes of Health (U.S.) (Grant R01EY007023) National Institutes of Health (U.S.) (Grant R01EY018648) 2015-03-17T21:04:57Z 2015-03-17T21:04:57Z 2010-09 2010-07 Article http://purl.org/eprint/type/JournalArticle 08966273 1097-4199 http://hdl.handle.net/1721.1/96068 Runyan, Caroline A., James Schummers, Audra Van Wart, Sandra J. Kuhlman, Nathan R. Wilson, Z. Josh Huang, and Mriganka Sur. “Response Features of Parvalbumin-Expressing Interneurons Suggest Precise Roles for Subtypes of Inhibition in Visual Cortex.” Neuron 67, no. 5 (September 9, 2010): 847–857. © 2010 Elsevier Inc https://orcid.org/0000-0002-6719-7085 https://orcid.org/0000-0003-2442-5671 en_US http://dx.doi.org/10.1016/j.neuron.2010.08.006 Neuron Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier |
| spellingShingle | Runyan, Caroline A. Schummers, James Van Wart, Audra Kuhlman, Sandra J. Wilson, Nathan R. Huang, Z. Josh Sur, Mriganka Response Features of Parvalbumin-Expressing Interneurons Suggest Precise Roles for Subtypes of Inhibition in Visual Cortex |
| title | Response Features of Parvalbumin-Expressing Interneurons Suggest Precise Roles for Subtypes of Inhibition in Visual Cortex |
| title_full | Response Features of Parvalbumin-Expressing Interneurons Suggest Precise Roles for Subtypes of Inhibition in Visual Cortex |
| title_fullStr | Response Features of Parvalbumin-Expressing Interneurons Suggest Precise Roles for Subtypes of Inhibition in Visual Cortex |
| title_full_unstemmed | Response Features of Parvalbumin-Expressing Interneurons Suggest Precise Roles for Subtypes of Inhibition in Visual Cortex |
| title_short | Response Features of Parvalbumin-Expressing Interneurons Suggest Precise Roles for Subtypes of Inhibition in Visual Cortex |
| title_sort | response features of parvalbumin expressing interneurons suggest precise roles for subtypes of inhibition in visual cortex |
| url | http://hdl.handle.net/1721.1/96068 https://orcid.org/0000-0002-6719-7085 https://orcid.org/0000-0003-2442-5671 |
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