Patient-Specific Simulation of Coronary Artery Pressure Measurements: An In Vivo Three-Dimensional Validation Study in Humans
Pressure measurements using finite element computations without the need of a wire could be valuable in clinical practice. Our aim was to compare the computed distal coronary pressure values with the measured values using a pressure wire, while testing the effect of different boundary conditions for...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://hdl.handle.net/1721.1/96118 https://orcid.org/0000-0002-5646-0378 |
| _version_ | 1811083733973860352 |
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| author | Siogkas, Panagiotis K. Sakellarios, Antonis I. Stefanou, Kostas A. Bourantas, Christos V. Athanasiou, Lambros S. Exarchos, Themis P. Naka, Katerina K. Michalis, Lampros K. Parodi, Oberdan Fotiadis, Dimitrios I. Papafaklis, Michail |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Siogkas, Panagiotis K. Sakellarios, Antonis I. Stefanou, Kostas A. Bourantas, Christos V. Athanasiou, Lambros S. Exarchos, Themis P. Naka, Katerina K. Michalis, Lampros K. Parodi, Oberdan Fotiadis, Dimitrios I. Papafaklis, Michail |
| author_sort | Siogkas, Panagiotis K. |
| collection | MIT |
| description | Pressure measurements using finite element computations without the need of a wire could be valuable in clinical practice. Our aim was to compare the computed distal coronary pressure values with the measured values using a pressure wire, while testing the effect of different boundary conditions for the simulation. Eight coronary arteries (lumen and outer vessel wall) from six patients were reconstructed in three-dimensional (3D) space using intravascular ultrasound and biplane angiographic images. Pressure values at the distal and proximal end of the vessel and flow velocity values at the distal end were acquired with the use of a combo pressure-flow wire. The 3D lumen and wall models were discretized into finite elements; fluid structure interaction (FSI) and rigid wall simulations were performed for one cardiac cycle both with pulsatile and steady flow in separate simulations. The results showed a high correlation between the measured and the computed coronary pressure values (coefficient of determination [r[superscript 2]] ranging between 0.8902 and 0.9961), while the less demanding simulations using steady flow and rigid walls resulted in very small relative error. Our study demonstrates that computational assessment of coronary pressure is feasible and seems to be accurate compared to the wire-based measurements. |
| first_indexed | 2024-09-23T12:38:12Z |
| format | Article |
| id | mit-1721.1/96118 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:38:12Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | mit-1721.1/961182022-10-01T10:09:57Z Patient-Specific Simulation of Coronary Artery Pressure Measurements: An In Vivo Three-Dimensional Validation Study in Humans Siogkas, Panagiotis K. Sakellarios, Antonis I. Stefanou, Kostas A. Bourantas, Christos V. Athanasiou, Lambros S. Exarchos, Themis P. Naka, Katerina K. Michalis, Lampros K. Parodi, Oberdan Fotiadis, Dimitrios I. Papafaklis, Michail Massachusetts Institute of Technology. Institute for Medical Engineering & Science Harvard University--MIT Division of Health Sciences and Technology Papafaklis, Michail Pressure measurements using finite element computations without the need of a wire could be valuable in clinical practice. Our aim was to compare the computed distal coronary pressure values with the measured values using a pressure wire, while testing the effect of different boundary conditions for the simulation. Eight coronary arteries (lumen and outer vessel wall) from six patients were reconstructed in three-dimensional (3D) space using intravascular ultrasound and biplane angiographic images. Pressure values at the distal and proximal end of the vessel and flow velocity values at the distal end were acquired with the use of a combo pressure-flow wire. The 3D lumen and wall models were discretized into finite elements; fluid structure interaction (FSI) and rigid wall simulations were performed for one cardiac cycle both with pulsatile and steady flow in separate simulations. The results showed a high correlation between the measured and the computed coronary pressure values (coefficient of determination [r[superscript 2]] ranging between 0.8902 and 0.9961), while the less demanding simulations using steady flow and rigid walls resulted in very small relative error. Our study demonstrates that computational assessment of coronary pressure is feasible and seems to be accurate compared to the wire-based measurements. European Union. European Regional Development Fund 2015-03-20T15:23:59Z 2015-03-20T15:23:59Z 2015 2014-04 2015-03-19T06:17:16Z Article http://purl.org/eprint/type/JournalArticle 2314-6133 2314-6141 http://hdl.handle.net/1721.1/96118 Siogkas, Panagiotis K. et al. “Patient-Specific Simulation of Coronary Artery Pressure Measurements: An In Vivo Three-Dimensional Validation Study in Humans.” BioMed Research International 2015 (2015): 1–11. https://orcid.org/0000-0002-5646-0378 en http://dx.doi.org/10.1155/2015/628416 BioMed Research International Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Copyright © 2015 Panagiotis K. Siogkas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf Hindawi Publishing Corporation Hindawi Publishing Corporation |
| spellingShingle | Siogkas, Panagiotis K. Sakellarios, Antonis I. Stefanou, Kostas A. Bourantas, Christos V. Athanasiou, Lambros S. Exarchos, Themis P. Naka, Katerina K. Michalis, Lampros K. Parodi, Oberdan Fotiadis, Dimitrios I. Papafaklis, Michail Patient-Specific Simulation of Coronary Artery Pressure Measurements: An In Vivo Three-Dimensional Validation Study in Humans |
| title | Patient-Specific Simulation of Coronary Artery Pressure Measurements: An In Vivo Three-Dimensional Validation Study in Humans |
| title_full | Patient-Specific Simulation of Coronary Artery Pressure Measurements: An In Vivo Three-Dimensional Validation Study in Humans |
| title_fullStr | Patient-Specific Simulation of Coronary Artery Pressure Measurements: An In Vivo Three-Dimensional Validation Study in Humans |
| title_full_unstemmed | Patient-Specific Simulation of Coronary Artery Pressure Measurements: An In Vivo Three-Dimensional Validation Study in Humans |
| title_short | Patient-Specific Simulation of Coronary Artery Pressure Measurements: An In Vivo Three-Dimensional Validation Study in Humans |
| title_sort | patient specific simulation of coronary artery pressure measurements an in vivo three dimensional validation study in humans |
| url | http://hdl.handle.net/1721.1/96118 https://orcid.org/0000-0002-5646-0378 |
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