Local Rule Simulations of Capsid Assembly
Local rules theory describes virus capsid self-assembly in terms of simple local binding preferences of discrete subunit conformations. The theory offered a parsimonious explanation for the complexity and regularity of virus capsids that resolved several inconsistencies between experimental observat...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://hdl.handle.net/1721.1/96131 https://orcid.org/0000-0002-2724-7228 https://orcid.org/0000-0003-4626-5648 |
| _version_ | 1826214077650698240 |
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| author | Schwartz, R. Shor, Peter W. Berger, Bonnie |
| author2 | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
| author_facet | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Schwartz, R. Shor, Peter W. Berger, Bonnie |
| author_sort | Schwartz, R. |
| collection | MIT |
| description | Local rules theory describes virus capsid self-assembly in terms of simple local binding preferences of discrete subunit conformations. The theory offered a parsimonious explanation for the complexity and regularity of virus capsids that resolved several inconsistencies between experimental observations and prior theories. Simultaneously, it provided a valuable practical abstraction for simulating the assembly process. Local rule models offered important advantages over other methods in rapidly developing simulations of complex geometries and assembly processes. Subsequent extensions considerably augmented the range of assembly phenomena amenable to simulation studies. Here we review the development of local rule-based simulation models and their applications to basic biology and medicine. We conclude by discussing the future prospects of local rule models for in silico experimentation with capsid assembly. |
| first_indexed | 2024-09-23T15:59:27Z |
| format | Article |
| id | mit-1721.1/96131 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:59:27Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | mit-1721.1/961312022-09-29T17:29:35Z Local Rule Simulations of Capsid Assembly Schwartz, R. Shor, Peter W. Berger, Bonnie Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology. Department of Mathematics Shor, Peter W. Berger, Bonnie Local rules theory describes virus capsid self-assembly in terms of simple local binding preferences of discrete subunit conformations. The theory offered a parsimonious explanation for the complexity and regularity of virus capsids that resolved several inconsistencies between experimental observations and prior theories. Simultaneously, it provided a valuable practical abstraction for simulating the assembly process. Local rule models offered important advantages over other methods in rapidly developing simulations of complex geometries and assembly processes. Subsequent extensions considerably augmented the range of assembly phenomena amenable to simulation studies. Here we review the development of local rule-based simulation models and their applications to basic biology and medicine. We conclude by discussing the future prospects of local rule models for in silico experimentation with capsid assembly. 2015-03-20T17:22:37Z 2015-03-20T17:22:37Z 2005-06 2015-03-19T11:37:08Z Article http://purl.org/eprint/type/JournalArticle 1027-3662 1607-8578 http://hdl.handle.net/1721.1/96131 Schwartz, R., P. W. Shor, and B. Berger. “Local Rule Simulations of Capsid Assembly.” Journal of Theoretical Medicine 6, no. 2 (2005): 81–85. © 2005 Hindawi Publishing Corporation https://orcid.org/0000-0002-2724-7228 https://orcid.org/0000-0003-4626-5648 en http://dx.doi.org/10.1080/10273660500149257 Journal of Theoretical Medicine Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf Hindawi Publishing Corporation Hindawi Publishing Corporation |
| spellingShingle | Schwartz, R. Shor, Peter W. Berger, Bonnie Local Rule Simulations of Capsid Assembly |
| title | Local Rule Simulations of Capsid Assembly |
| title_full | Local Rule Simulations of Capsid Assembly |
| title_fullStr | Local Rule Simulations of Capsid Assembly |
| title_full_unstemmed | Local Rule Simulations of Capsid Assembly |
| title_short | Local Rule Simulations of Capsid Assembly |
| title_sort | local rule simulations of capsid assembly |
| url | http://hdl.handle.net/1721.1/96131 https://orcid.org/0000-0002-2724-7228 https://orcid.org/0000-0003-4626-5648 |
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