Can We Build Artificial Stem Cell Compartments?
Animals carry stem cells throughout their entire life, from embryogenesis to senescence. Their function during development and adulthood consists basically of forming and sustaining functional tissues while maintaining a small self-renewing population. They reside in a complex three-dimensional envi...
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2015
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| Online Access: | http://hdl.handle.net/1721.1/96133 |
| _version_ | 1811074152848687104 |
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| author | Semino, Carlos E. |
| author2 | Massachusetts Institute of Technology. Biotechnology Process Engineering Center |
| author_facet | Massachusetts Institute of Technology. Biotechnology Process Engineering Center Semino, Carlos E. |
| author_sort | Semino, Carlos E. |
| collection | MIT |
| description | Animals carry stem cells throughout their entire life, from embryogenesis to senescence. Their function during development and adulthood consists basically of forming and sustaining functional tissues while maintaining a small self-renewing population. They reside in a complex three-dimensional environment consisting of other nearby cells extracellular matrix components, endogenous or exogenous soluble factors, and physical, structural, or mechanical properties of the tissues they inhabit. Can we artificially recreate tissue development such that stem cells can both self-renew and be instructed to mature properly? The main factors required to regulate the maintenance and differentiation of some types of stem cells are known. In addition, new bioengineered synthetic materials that mimic extracellular matrix components can be used as initial scaffolding for building stem cell microenvironments. |
| first_indexed | 2024-09-23T09:44:16Z |
| format | Article |
| id | mit-1721.1/96133 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:44:16Z |
| publishDate | 2015 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | mit-1721.1/961332022-09-26T13:24:44Z Can We Build Artificial Stem Cell Compartments? Semino, Carlos E. Massachusetts Institute of Technology. Biotechnology Process Engineering Center Massachusetts Institute of Technology. Department of Biological Engineering Semino, Carlos E. Animals carry stem cells throughout their entire life, from embryogenesis to senescence. Their function during development and adulthood consists basically of forming and sustaining functional tissues while maintaining a small self-renewing population. They reside in a complex three-dimensional environment consisting of other nearby cells extracellular matrix components, endogenous or exogenous soluble factors, and physical, structural, or mechanical properties of the tissues they inhabit. Can we artificially recreate tissue development such that stem cells can both self-renew and be instructed to mature properly? The main factors required to regulate the maintenance and differentiation of some types of stem cells are known. In addition, new bioengineered synthetic materials that mimic extracellular matrix components can be used as initial scaffolding for building stem cell microenvironments. 2015-03-20T17:52:05Z 2015-03-20T17:52:05Z 2003 2002-05 2015-03-19T11:37:22Z Article http://purl.org/eprint/type/JournalArticle 1110-7243 1110-7251 http://hdl.handle.net/1721.1/96133 Semino, Carlos E. “Can We Build Artificial Stem Cell Compartments?” Journal of Biomedicine and Biotechnology 2003, no. 3 (2003): 164–169. © 2003 Hindawi Publishing Corporation en http://dx.doi.org/10.1155/S1110724303208019 Journal of Biomedicine and Biotechnology Creative Commons Attribution http://creativecommons.org/licenses/by/2.0 Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf Hindawi Publishing Corporation Hindawi Publishing Corporation |
| spellingShingle | Semino, Carlos E. Can We Build Artificial Stem Cell Compartments? |
| title | Can We Build Artificial Stem Cell Compartments? |
| title_full | Can We Build Artificial Stem Cell Compartments? |
| title_fullStr | Can We Build Artificial Stem Cell Compartments? |
| title_full_unstemmed | Can We Build Artificial Stem Cell Compartments? |
| title_short | Can We Build Artificial Stem Cell Compartments? |
| title_sort | can we build artificial stem cell compartments |
| url | http://hdl.handle.net/1721.1/96133 |
| work_keys_str_mv | AT seminocarlose canwebuildartificialstemcellcompartments |