Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast
Eukaryotic organisms age, yet detrimental age-associated traits are not passed on to progeny. How life span is reset from one generation to the next is not known. We show that in budding yeast resetting of life span occurs during gametogenesis. Gametes (spores) generated by aged cells show the same...
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Association for the Advancement of Science (AAAS)
2015
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| Online Access: | http://hdl.handle.net/1721.1/96160 https://orcid.org/0000-0001-9837-0314 |
| _version_ | 1811076602335854592 |
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| author | Kinde, B. Unal, Elcin Amon, Angelika B |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Kinde, B. Unal, Elcin Amon, Angelika B |
| author_sort | Kinde, B. |
| collection | MIT |
| description | Eukaryotic organisms age, yet detrimental age-associated traits are not passed on to progeny. How life span is reset from one generation to the next is not known. We show that in budding yeast resetting of life span occurs during gametogenesis. Gametes (spores) generated by aged cells show the same replicative potential as gametes generated by young cells. Age-associated damage is no longer detectable in mature gametes. Furthermore, transient induction of a transcription factor essential for later stages of gametogenesis extends the replicative life span of aged cells. Our results indicate that gamete formation brings about rejuvenation by eliminating age-induced cellular damage. |
| first_indexed | 2024-09-23T10:24:45Z |
| format | Article |
| id | mit-1721.1/96160 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:24:45Z |
| publishDate | 2015 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/961602022-09-30T20:55:54Z Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast Kinde, B. Unal, Elcin Amon, Angelika B Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Amon, Angelika B. Unal, Elcin Eukaryotic organisms age, yet detrimental age-associated traits are not passed on to progeny. How life span is reset from one generation to the next is not known. We show that in budding yeast resetting of life span occurs during gametogenesis. Gametes (spores) generated by aged cells show the same replicative potential as gametes generated by young cells. Age-associated damage is no longer detectable in mature gametes. Furthermore, transient induction of a transcription factor essential for later stages of gametogenesis extends the replicative life span of aged cells. Our results indicate that gamete formation brings about rejuvenation by eliminating age-induced cellular damage. National Institutes of Health (U.S.) (Grant GM62207) 2015-03-24T19:41:25Z 2015-03-24T19:41:25Z 2011-06 2011-02 Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 http://hdl.handle.net/1721.1/96160 Unal, E., B. Kinde, and A. Amon. “Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast.” Science 332, no. 6037 (June 23, 2011): 1554–1557. https://orcid.org/0000-0001-9837-0314 en_US http://dx.doi.org/10.1126/science.1204349 Science Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) PMC |
| spellingShingle | Kinde, B. Unal, Elcin Amon, Angelika B Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast |
| title | Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast |
| title_full | Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast |
| title_fullStr | Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast |
| title_full_unstemmed | Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast |
| title_short | Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast |
| title_sort | gametogenesis eliminates age induced cellular damage and resets life span in yeast |
| url | http://hdl.handle.net/1721.1/96160 https://orcid.org/0000-0001-9837-0314 |
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