Wnt Signaling and the Polarity of the Primary Body Axis
How animals establish and pattern the primary body axis is one of the most fundamental problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) and from planarians (protostomes) suggest that Wnt signaling through β-catenin controls posterior identity during body plan f...
| मुख्य लेखकों: | , |
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| अन्य लेखक: | |
| स्वरूप: | लेख |
| भाषा: | en_US |
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Elsevier
2015
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| ऑनलाइन पहुंच: | http://hdl.handle.net/1721.1/96176 https://orcid.org/0000-0002-5569-333X |
| _version_ | 1826199117552943104 |
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| author | Petersen, Christian P. Reddien, Peter |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Petersen, Christian P. Reddien, Peter |
| author_sort | Petersen, Christian P. |
| collection | MIT |
| description | How animals establish and pattern the primary body axis is one of the most fundamental problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) and from planarians (protostomes) suggest that Wnt signaling through β-catenin controls posterior identity during body plan formation in most bilaterally symmetric animals. Wnt signaling also influences primary axis polarity of pre-bilaterian animals, indicating that an axial patterning role for Wnt signaling predates the evolution of bilaterally symmetric animals. The use of posterior Wnt signaling and anterior Wnt inhibition might be a unifying principle of body plan development in most animals. |
| first_indexed | 2024-09-23T11:15:00Z |
| format | Article |
| id | mit-1721.1/96176 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:15:00Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/961762022-10-01T02:19:17Z Wnt Signaling and the Polarity of the Primary Body Axis Petersen, Christian P. Reddien, Peter Massachusetts Institute of Technology. Department of Biology Whitehead Institute for Biomedical Research Reddien, Peter How animals establish and pattern the primary body axis is one of the most fundamental problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) and from planarians (protostomes) suggest that Wnt signaling through β-catenin controls posterior identity during body plan formation in most bilaterally symmetric animals. Wnt signaling also influences primary axis polarity of pre-bilaterian animals, indicating that an axial patterning role for Wnt signaling predates the evolution of bilaterally symmetric animals. The use of posterior Wnt signaling and anterior Wnt inhibition might be a unifying principle of body plan development in most animals. National Institutes of Health (U.S.) (R01GM080639) American Cancer Society (RSG-07-180-01-DDC) Rita Allen Foundation Searle Scholars Program Smith Foundation W. M. Keck Foundation 2015-03-25T16:09:38Z 2015-03-25T16:09:38Z 2009-12 Article http://purl.org/eprint/type/JournalArticle 00928674 1097-4172 http://hdl.handle.net/1721.1/96176 Petersen, Christian P., and Peter W. Reddien. “Wnt Signaling and the Polarity of the Primary Body Axis.” Cell 139, no. 6 (December 2009): 1056–1068. © 2009 Elsevier Inc. https://orcid.org/0000-0002-5569-333X en_US http://dx.doi.org/10.1016/j.cell.2009.11.035 Cell Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Elsevier Elsevier |
| spellingShingle | Petersen, Christian P. Reddien, Peter Wnt Signaling and the Polarity of the Primary Body Axis |
| title | Wnt Signaling and the Polarity of the Primary Body Axis |
| title_full | Wnt Signaling and the Polarity of the Primary Body Axis |
| title_fullStr | Wnt Signaling and the Polarity of the Primary Body Axis |
| title_full_unstemmed | Wnt Signaling and the Polarity of the Primary Body Axis |
| title_short | Wnt Signaling and the Polarity of the Primary Body Axis |
| title_sort | wnt signaling and the polarity of the primary body axis |
| url | http://hdl.handle.net/1721.1/96176 https://orcid.org/0000-0002-5569-333X |
| work_keys_str_mv | AT petersenchristianp wntsignalingandthepolarityoftheprimarybodyaxis AT reddienpeter wntsignalingandthepolarityoftheprimarybodyaxis |