Reading the Book of Memory: Sparse Sampling versus Dense Mapping of Connectomes

Many theories of neural networks assume rules of connection between pairs of neurons that are based on their cell types or functional properties. It is finally becoming feasible to test such pairwise models of connectivity, due to emerging advances in neuroanatomical techniques. One method will be t...

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Bibliographic Details
Main Author: Seung, H. Sebastian
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:en_US
Published: Elsevier 2015
Online Access:http://hdl.handle.net/1721.1/96185
Description
Summary:Many theories of neural networks assume rules of connection between pairs of neurons that are based on their cell types or functional properties. It is finally becoming feasible to test such pairwise models of connectivity, due to emerging advances in neuroanatomical techniques. One method will be to measure the functional properties of connected pairs of neurons, sparsely sampling pairs from many specimens. Another method will be to find a “connectome,” a dense map of all connections in a single specimen, and infer functional properties of neurons through computational analysis. For the latter method, the most exciting prospect would be to decode the memories that are hypothesized to be stored in connectomes.