Standard Thermodynamic Functions of Tripeptides N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalaninol and N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalanine Methyl Ester
The heat capacities of tripeptides N-formyl-l-methionyl-l-leucyl-l-phenylalaninol (N-f-MLF-OH) and N-formyl-l-methionyl-l-leucyl-l-phenylalanine methyl ester (N-f-MLF-OMe) were measured by precision adiabatic vacuum calorimetry over the temperature range from T = (6 to 350) K. The tripeptides were s...
| Main Authors: | , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
American Chemical Society (ACS)
2015
|
| Online Access: | http://hdl.handle.net/1721.1/96212 https://orcid.org/0000-0003-1589-832X |
| _version_ | 1811080480947175424 |
|---|---|
| author | Markin, Alexey V. Markhasin, Evgeny Sologubov, Semen S. Smirnova, Natalia N. Griffin, Robert Guy |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Markin, Alexey V. Markhasin, Evgeny Sologubov, Semen S. Smirnova, Natalia N. Griffin, Robert Guy |
| author_sort | Markin, Alexey V. |
| collection | MIT |
| description | The heat capacities of tripeptides N-formyl-l-methionyl-l-leucyl-l-phenylalaninol (N-f-MLF-OH) and N-formyl-l-methionyl-l-leucyl-l-phenylalanine methyl ester (N-f-MLF-OMe) were measured by precision adiabatic vacuum calorimetry over the temperature range from T = (6 to 350) K. The tripeptides were stable over this temperature range, and no phase change, transformation, association, or thermal decomposition was observed. The standard thermodynamic functions: molar heat capacity C[subscript p,m], enthalpy H(T) – H(0), entropy S(T), and Gibbs energy G(T) – H(0) of peptides were calculated over the range from T = (0 to 350) K. The low-temperature (T ≤ 50 K) heat capacities dependencies were analyzed using the Debye’s and the multifractal theories. The standard entropies of formation of peptides at T = 298.15 K were calculated. |
| first_indexed | 2024-09-23T11:32:22Z |
| format | Article |
| id | mit-1721.1/96212 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:32:22Z |
| publishDate | 2015 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/962122022-10-01T04:16:26Z Standard Thermodynamic Functions of Tripeptides N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalaninol and N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalanine Methyl Ester Markin, Alexey V. Markhasin, Evgeny Sologubov, Semen S. Smirnova, Natalia N. Griffin, Robert Guy Massachusetts Institute of Technology. Department of Chemistry Markhasin, Evgeny Griffin, Robert Guy The heat capacities of tripeptides N-formyl-l-methionyl-l-leucyl-l-phenylalaninol (N-f-MLF-OH) and N-formyl-l-methionyl-l-leucyl-l-phenylalanine methyl ester (N-f-MLF-OMe) were measured by precision adiabatic vacuum calorimetry over the temperature range from T = (6 to 350) K. The tripeptides were stable over this temperature range, and no phase change, transformation, association, or thermal decomposition was observed. The standard thermodynamic functions: molar heat capacity C[subscript p,m], enthalpy H(T) – H(0), entropy S(T), and Gibbs energy G(T) – H(0) of peptides were calculated over the range from T = (0 to 350) K. The low-temperature (T ≤ 50 K) heat capacities dependencies were analyzed using the Debye’s and the multifractal theories. The standard entropies of formation of peptides at T = 298.15 K were calculated. National Institute for Biomedical Imaging and Bioengineering (U.S.) (Grant EB-003151) National Institute for Biomedical Imaging and Bioengineering (U.S.) (Grant EB-001960) National Institute for Biomedical Imaging and Bioengineering (U.S.) (Grant EB-002026) Ministry of Education and Science of the Russian Federation (Contract 14.B37.21.0799) 2015-03-27T15:35:29Z 2015-03-27T15:35:29Z 2014-03 2013-10 Article http://purl.org/eprint/type/JournalArticle 0021-9568 1520-5134 http://hdl.handle.net/1721.1/96212 Markin, Alexey V., Evgeny Markhasin, Semen S. Sologubov, Natalia N. Smirnova, and Robert G. Griffin. “Standard Thermodynamic Functions of Tripeptides N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalaninol and N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalanine Methyl Ester.” Journal of Chemical & Engineering Data 59, no. 4 (April 10, 2014): 1240–1246. © 2014 American Chemical Society https://orcid.org/0000-0003-1589-832X en_US http://dx.doi.org/10.1021/je400879v Journal of Chemical & Engineering Data Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) ACS |
| spellingShingle | Markin, Alexey V. Markhasin, Evgeny Sologubov, Semen S. Smirnova, Natalia N. Griffin, Robert Guy Standard Thermodynamic Functions of Tripeptides N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalaninol and N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalanine Methyl Ester |
| title | Standard Thermodynamic Functions of Tripeptides N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalaninol and N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalanine Methyl Ester |
| title_full | Standard Thermodynamic Functions of Tripeptides N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalaninol and N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalanine Methyl Ester |
| title_fullStr | Standard Thermodynamic Functions of Tripeptides N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalaninol and N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalanine Methyl Ester |
| title_full_unstemmed | Standard Thermodynamic Functions of Tripeptides N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalaninol and N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalanine Methyl Ester |
| title_short | Standard Thermodynamic Functions of Tripeptides N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalaninol and N-Formyl-L-Methionyl-L-Leucyl-L-Phenylalanine Methyl Ester |
| title_sort | standard thermodynamic functions of tripeptides n formyl l methionyl l leucyl l phenylalaninol and n formyl l methionyl l leucyl l phenylalanine methyl ester |
| url | http://hdl.handle.net/1721.1/96212 https://orcid.org/0000-0003-1589-832X |
| work_keys_str_mv | AT markinalexeyv standardthermodynamicfunctionsoftripeptidesnformyllmethionyllleucyllphenylalaninolandnformyllmethionyllleucyllphenylalaninemethylester AT markhasinevgeny standardthermodynamicfunctionsoftripeptidesnformyllmethionyllleucyllphenylalaninolandnformyllmethionyllleucyllphenylalaninemethylester AT sologubovsemens standardthermodynamicfunctionsoftripeptidesnformyllmethionyllleucyllphenylalaninolandnformyllmethionyllleucyllphenylalaninemethylester AT smirnovanatalian standardthermodynamicfunctionsoftripeptidesnformyllmethionyllleucyllphenylalaninolandnformyllmethionyllleucyllphenylalaninemethylester AT griffinrobertguy standardthermodynamicfunctionsoftripeptidesnformyllmethionyllleucyllphenylalaninolandnformyllmethionyllleucyllphenylalaninemethylester |